A Comparative Perspective on Ribosome Biogenesis: Unity and Diversity Across the Tree of Life

Jüttner, Michael; Ferreira-Cerca, Sébastien

doi:10.1007/978-1-0716-2501-9_1

Cited by 15 publications

(9 citation statements)

References 169 publications

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“…In eukaryotes, the 40S SSU contains the 18S rRNA and 33 proteins. The eukaryotic LSU is made up of three rRNAs, 5S, 5.8S, and 25S/28S, and 49 proteins [ 13 ]. The rRNAs function as the catalytic core of the ribosome carrying approximately 55% of the ribosome mass and 80% of the total mass of cellular RNA content.…”

Section: Introductionmentioning

confidence: 99%

Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging

Islam

Rallis

2023

Epigenomes

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Although reported in the literature, ribosome heterogeneity is a phenomenon whose extent and implications in cell and organismal biology is not fully appreciated. This has been the case due to the lack of the appropriate techniques and approaches. Heterogeneity can arise from alternative use and differential content of protein and RNA constituents, as well as from post-transcriptional and post-translational modifications. In the few examples we have, it is apparent that ribosomal heterogeneity offers an additional level and potential for gene expression regulation and might be a way towards tuning metabolism, stress, and growth programs to external and internal stimuli and needs. Here, we introduce ribosome biogenesis and discuss ribosomal heterogeneity in various reported occasions. We conclude that a systematic approach in multiple organisms will be needed to delineate this biological phenomenon and its contributions to growth, aging, and disease. Finally, we discuss ribosome mutations and their roles in disease.

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Section: Introductionmentioning

confidence: 99%

Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging

Islam

Rallis

2023

Epigenomes

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“…Additionally, in extreme cases such as Chlamydomonas reinhardtii (37), rRNA is arranged into a scrambled genome. Given the typically high conservation of ribosomal structures among various strains (38)(39)(40), the robust docking hierarchy of rRNA offers theoretical plausibility for the successful biogenesis of such a scrambled rRNA genome.…”

Section: Discussionmentioning

confidence: 99%

Assembly of the Bacterial Ribosome with Circularly Permuted rRNA

Dong,

Sheng,

Gebert

et al. 2024

Preprint

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Co-transcriptional assembly is an integral feature of the formation of RNA-protein complexes that mediate translation. For ribosome synthesis, prior studies have indicated that the strict order of transcription of rRNA domains may not be obligatory during bacterial ribosome biogenesis, since a series of circularly permuted rRNAs are viable. In this work, we report the insights into assembly of the bacterial ribosome large subunit (LSU) based on cryo-EM density maps of intermediates that accumulate during in vitro ribosome synthesis using a set of circularly permuted (CiPer) rRNAs. The observed ensemble of twenty-three resolved ribosome large subunit intermediates reveals conserved assembly routes with an underlying hierarchy among cooperative assembly blocks. There are intricate interdependencies for the formation of key structural rRNA helices revealed from the circular permutation of rRNA. While the order of domain synthesis is not obligatory, the order of domain association does appear to proceed with a particular order, likely due to the strong evolutionary pressure on efficient ribosome synthesis. This work reinforces the robustness of the known assembly hierarchy of the bacterial large ribosomal subunit, and offers a coherent view of how efficient assembly of CiPer rRNAs can be understood in that context.

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“…Ribosome biogenesis in eukaryotes is the basis of cell life and most cellular processes, including growth and cell division [51]. Some scholars have found that destroying the intracellular zinc homeostasis of C. albicans inhibits ribosome biogenesis in eukaryotes and then selectively inhibits mitochondrial respiration to prevent fungal contamination [52].…”

Section: Discussionmentioning

confidence: 99%

Study on the inhibitory activity and mechanism of Mentha haplocalyx essential oils nanoemulsion against Fusarium oxysporum growth

Liao,

Wen,

Nie

et al. 2024

Preprint

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As a green and environmentally friendly natural product, Mentha haplocalyx essential oil (MEO) inhibits F. oxysporum, but its field application is limited by its poor water solubility. The nanoemulsion can improve bioavailability and provide a green way to prevent and control P. notoginseng root rot. In this study, Tween-80 and anhydrous ethanol were selected as carriers, and the ultrasonic method was adopted to prepare a nanoemulsion of MEO (MNEO) with an average particle size of 26.07 nm. Compared with traditional emulsion of MEO (MTEO, MEO dissolved in an aqueous solution of 2% DMSO and 0.1% Tween 80), MNEO was superior in inhibiting F. oxysporum in terms of spore germination, hyphal growth, and minimum inhibitory concentration (MIC). Through transcriptomic and metabolomic analyses, it was found that both MNEO and MTEO can inhibit the Glycolysis/Gluconeogenesis and Starch and Sucrose metabolism pathways of F. oxysporum. Nevertheless, MNEO can inhibit the expression of more genes and metabolites. In addition, some key genes in meiosis, ribosome, and ribosome biogenesis were also significantly downregulated only under MNEO treatment. These genes and metabolites provide valuable information for the later prevention and control of F. oxysporum and provide a theoretical basis for better utilization of MEO resources to develop plant-derived bacteriostatic agents and agricultural modernization and ecological development.

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A Comparative Perspective on Ribosome Biogenesis: Unity and Diversity Across the Tree of Life

Cited by 15 publications

References 169 publications

Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging

Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging

Assembly of the Bacterial Ribosome with Circularly Permuted rRNA

Study on the inhibitory activity and mechanism of Mentha haplocalyx essential oils nanoemulsion against Fusarium oxysporum growth

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