A comparative pharmacological investigation of Ashwagandha and Ginseng

Grandhi, Anuradha; Mujumdar, A. M.; Patwardhan, Bhushan

doi:10.1016/0378-8741(94)01119-2

Cited by 114 publications

(41 citation statements)

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“…Our results showed that, the single IP LD 50 of WS alcoholic extract (areal parts), 24 hours after injection, was 522.27 mg/kg bwt. This result is contradictory with those of Grandhi, et al (1994) where their recorded IP LD 50 was 1076 ±78 mg/kg bwt. in mice and 1260 mg/kg bwt.…”

Section: Discussioncontrasting

confidence: 55%

“…Moreover, the acute oral LD 50 of alcohol extract from defatted WS seeds dissolved in normal saline was 1750 ± 41 mg/kg in albino mice (Singh, et al 1982). In another study, the acute IP LD 50 of aqueous-methanol extracts of WS roots from one-year-old cultivated WS injected in mice was 1076 ±78 mg/kg (Grandhi, et al 1994). Despite the wide use of WS plant as food and medicine in traditional societies of Africa and Asia, including Saudi Arabia, reports of toxicity studies, either on WS root or whole plant or different extracts of the plant, are still limited.…”

Section: Introductionmentioning

confidence: 99%

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Acute and Sub-Chronic Toxicological Potential of Withania Somnifera Extract on Rats

Hussein¹,

Al-Shokair²,

Ashry³

2017

AJVS

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Key words:Withania somnifera, lethal dose fifty, sub chronic toxicity, ashwagandah Withania somnifera (WS) has a wide range of therapeutic applications for several disorders. Toxicity studies on WS are very limited. The purpose of the present work was to study the acute and sub-chronic toxicity of WS extracts in rats and to determine the LD 50 value, which in turn helps in determining the dose range for the plant extract to be used with no harmful or lethal effects on the animal. Rats in acute study were IP injected with the alcoholic extract of WS (the aerial parts) at doses of (0), 150, 300, 600 and 1200 mg/kg bwt. In subchronic toxicity study WS extract was administered IP at a dose of 10%, 20% and 40% of the obtained LD 50 (52 mg/kg bwt, 104 mg/kg bwt and 208 mg/kg bwt respectively) for 60 days. Acute toxicity revealed an IP LD 50 of 522 mg/kg wt. Significant changes in body weight, hematological, biochemical and histopathological changes were recorded in 20% and 40% LD 50 groups with 15 -40 % mortalities respectively, by the end of the experiments. Based on this study, WS showed toxicity at doses higher than 10% LD 50 when given IP and it was suggested to use ≤ 10% LD 50 (IP) doses of WS extracts, than the tested here to start with in setup protection or treatment studies.Correspondence to: Khaled M.Ashry : ashrykh@yahoo.com

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Acute and Sub-Chronic Toxicological Potential of Withania Somnifera Extract on Rats

Hussein¹,

Al-Shokair²,

Ashry³

2017

AJVS

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“…Glycowithanolides and sitoindosides IX and X are responsible for the immunomodulatory activity. The withanolides, sitoindosides, and withaferine A of W. somnifera are responsible for its antioxidant activity [102][103][104][105].…”

Section: Caterpillar Fungus (Botanical Name: Cordyceps Sinensis (Clavmentioning

confidence: 99%

Herbal Drugs in Chronic Fatigue Syndrome: An Overview

Semalty

Panda

et al. 2012

Schweiz Z Ganzheitsmed

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Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue of 6 months or longer duration that is not improved by bed rest and that may be worsened by physical or mental activity. It is often age-related and may coexist with other diseases such as multiple sclerosis, Parkinson’s disease, depression, cancer, HIV infection etc. Persons with CFS most often function at a substantially lower level of activity than they were capable of before the onset of illness. Modern medicine has limited therapies and those offered by it have strong side-effects. On the other hand, various traditional systems of medicine such as the Chinese herbal system and Ayurveda offer several botanicals, especially the adaptogens, which have been used to combat chronic fatigue effectively. Literature reports a plethora of animal and clinical studies on the safety and efficacy of these plant drugs. The present article extensively reviews CFS, its pathophysiology, and its pharmacological treatment, with a special emphasis on herbal drugs such as Cat’s claw, Ginseng, caterpillar fungus, ashwagandha, Tulsi, jiaogulan etc. The botanical therapies discussed here are very commonly used drugs with profound data available on them.

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“…Steroids present in WS are also known as withanolides 10 . These steroidal compounds have been used to reduce stress, reduce cholesterol levels, activate immune system, enhance memory and learning and to treat tumor cells in cancer cases [25][26][27] . Tannins are attributed with analgesic and antiinflammatory activities.…”

Section: Flavonoidsmentioning

confidence: 99%

Untitled

2013

IJPSR

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ABSTRACT:Medicinal plants are a source of naturally active compounds used extensively by tribal people worldwide for many ailments. Withania somnifera (WS) is one such plant used to treat many ailments from the time of Ayurveda. Extraction of the bioactive plant constituents from the whole plant or from the different parts of the plant has always been a challenging task. As the dried roots of WS are widely used in the treatment of many disorders, the current investigation aimed at extraction and detection or screening of active phytochemical compounds from different extracts of WS root. Phytochemical screening of different extractions revealed the presence of phenols, flavonoids, tannins, saponins, alkaloids, steroids, terpenoids, glycosides and reducing sugars which could account for its varied medicinal properties like anti-inflammatory, anti-spasmodic, anti-analgesic, neuroprotective and diurectic effects. INTRODUCTION:For over a decade, interest has been revived in the study and use of traditional medicine in different parts of the world. As a result, countries have sought cooperation in identifying and using safe positive components of traditional medicine in their national health systems 1 .

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A comparative pharmacological investigation of Ashwagandha and Ginseng

Cited by 114 publications

References 1 publication

Acute and Sub-Chronic Toxicological Potential of Withania Somnifera Extract on Rats

Acute and Sub-Chronic Toxicological Potential of Withania Somnifera Extract on Rats

Herbal Drugs in Chronic Fatigue Syndrome: An Overview

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