A comparative pharmacological study on the effect of Tagara (Valeriana wallichii) AND Jatamansi (Nardostachys jatamansi) in the management of anidra w.s.r to primary insomnia

Abstract

The present study was undertaken to evaluate Tagara and Jatamansi for certain CNS activities to ascertain the basis for their use as a sedative and hypnotics. The drugs were evaluated for hypnotic and sedative, anti anxiety, anti depressant and anti psychotic activities using standard experimental protocol. The data generated suggests that the test drugs Tagara and Jatamansi have complex CNS activity profile which is not easy to categorize under general CNS activity profile. Both possess significant anti-anxiety activity without significant sedative-hypnotic activity. This increases their utility for the patients suffering from anxiety due to sleep disturbances.

Nardostachys jatamansi: A Review on Extraction Isolation Bioactivities of Phytoconstituents Chemical Structures and Traditional Uses

“…This makes them more effective in treating anxiety neurosis. 82 Anti-diabetic Hydroalcoholic extracts in rats with diabetes caused by alloxan. 83 Anti-diuretic Urine and electrolyte excretion increased in a dose-dependent manner when petroleum ether and ethanol extracts were used.…”

Anxiety and Depression management through Ayurveda drugs and Panchakarma

“…It is also beneficial in managing blood pressure by relaxing smooth muscles and increasing the blood flow. [2] 3) Mandukparni (Centella asiatica) -contains brahminoside, brahmoside which binds to cholecystokinin receptors, a group of G protein coupled receptors which bind the peptide hormones cholesystokinin and play a potential role in modulation of anxiety. [3] 4) Shankahpuspi (Convulvulus pleuricalis) -it balances the neurotransmitters and ups the dopamine secretion which inturn keeps the serotonin level under control and helps to reduce symptoms of anxiety.…”

“…5) Jatamansi (Nardostachys jatamansi) -increases in the levels of monoamines and inhibitory amino acids, serotonin, 5-hydroxyindole acetic acid, gaba and taurine contributes to its antidepressant action. [5] 6) Ashwagandha (Withania somnifera) -stabilizing effect on the HPA axis where it becomes less reactive to stressors. It reduces cortisol and DHEA-S levels suggesting it has moderating effect on HPA axis activity in stressed adults.…”