1988
DOI: 10.1002/jbm.820220108
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A comparative scanning electron microscopic study on degradation of absorbable ligating clips in vivo and in vitro

Abstract: Using scanning electron microscopy, the degradation characteristics of two absorbable ligating clips, Absolok (polydioxanone) and Lactomer (poly-L-lactide-co-30%-glycolide) have been studied under in vivo and in vitro conditions. The rate of Absolok clip degradation was significantly greater than that of Lactomer clip degradation both in vitro and in vivo. The rate of degradation of Lactomer clips significantly increased and they showed a greater change in proportion of breakdown in vivo than in vitro compared… Show more

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Cited by 23 publications
(8 citation statements)
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“…The in vitro and in vivo degradation results in the current investigation show the same tendency as in previous reports, in which the polymers degraded significantly faster in vivo than in an in vitro environment. 40,42,43 Although the stiff and flexible PLLA cages showed an advanced reduction in inherent viscosity (64% and 81%, respectively) after 6 months of implantation, radiographic evaluation disclosed no evidence of cage collapse in terms of alteration in cage configuration. On the contrary, macroscopic and microscopic evaluation disclosed that the stiff and flexible PLLA cages had maintained their original height of 10 mm, both after 3 and 6 months of implantation.…”
Section: Discussionmentioning
confidence: 92%
“…The in vitro and in vivo degradation results in the current investigation show the same tendency as in previous reports, in which the polymers degraded significantly faster in vivo than in an in vitro environment. 40,42,43 Although the stiff and flexible PLLA cages showed an advanced reduction in inherent viscosity (64% and 81%, respectively) after 6 months of implantation, radiographic evaluation disclosed no evidence of cage collapse in terms of alteration in cage configuration. On the contrary, macroscopic and microscopic evaluation disclosed that the stiff and flexible PLLA cages had maintained their original height of 10 mm, both after 3 and 6 months of implantation.…”
Section: Discussionmentioning
confidence: 92%
“…Resorbable large implants made of polylactic acid and/or polyglycolic acid have been described for more than 10 years 5‐12 . Resorbable small implants in the form of suture material have been evaluated over an even longer time 13‐16 …”
Section: Discussionmentioning
confidence: 99%
“…Polyglycolic acid polymers have a more amorphous hydrophilic 11,15 structure and a consequently faster resorption rate. Final biochemical degradation of these polyesters is via the citric acid cycle, with eventual respiratory elimination of the carbon dioxide thus produced 2 .…”
Section: Discussionmentioning
confidence: 99%
“…When exposed to water, the ester groups of the PLA material are cleaved, resulting in slow degradation of the polyester. 14 Polyglycolic acid polymers are chemically hydrophilic and therefore resorb at a faster rate than PLA products. Combining the PLA/PGA polymers in varying concentrations can alter the resorption rates of the fixation plates.…”
Section: Methodsmentioning
confidence: 99%