A Comparative Solubility Enhancement Study of Cefixime Trihydrate Using Different Dispersion Techniques

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“…Solid Dispersion by Hot Melt Method: 8 Solid dispersions of RN in different ratios of drug to polymer ratio (1:1, 1:2, 1:3, and 1:4) were prepared by hot-melt method as follows. Accurately weighed polymers (PEG 4000& PEG 6000 in equal quantity) were melted on a water bath at 70 °C.…”

“…Method: 8 Solid dispersions of RN in different ratios of drug to polymer ratio (1:1, 1:2, 1:3, and 1:4) were prepared by solvent evaporation method as follows. Accurately weighed drug was dissolved in 10 ml methanol, and weighed quantity of polymer PVP K-30 in the respective ratios was dissolved in 10mL of ethanol.…”

“…An equal volume of fresh medium at the same temperature was replaced into the dissolution medium after each sampling to maintain its constant volume throughout the test. Each test was performed in triplicate (n=3), and calculated mean values of cumulative drug release were used for plotting curves 8,9,11 .…”

Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for Pediatric Use

“…The very low aqueous solubility of CEF contributes to its low a from the gastrointestinal tract [13] and makes it difficult the deve formulations. Several efforts have been performed to overcome this im including preparation of CEF amorphous nanoparticles [14,15] different coformers [16], as well as the use of solid dispersions with d carriers [17][18][19] or of cyclodextrins, alone or in combination with other Moreover, the impact of the above manipulations on the drug bioavailability is often unknown, and these extemporaneous formulations can have limited and unknown physical, chemical and microbiological stability, leading to enhanced risks of medication errors, and the appearance of adverse reactions [4][5][6][7].…”

“…The very low aqueous solubility of CEF contributes to its low absorption (40-50%) from the gastrointestinal tract [13] and makes it difficult the development of liquid formulations. Several efforts have been performed to overcome this important drawback, including preparation of CEF amorphous nanoparticles [14,15] or cocrystals with different coformers [16], as well as the use of solid dispersions with different hydrophilic carriers [17][18][19] or of cyclodextrins, alone or in combination with other solubilizing agents [20,21].…”