A comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteria

Swar, Sumita; Máková, Veronika; Horakova, Jana; Kejzlar, Pavel; Parma, Petr; Stibor, Ivan

doi:10.1016/j.eurpolymj.2019.109392

Cited by 14 publications

(16 citation statements)

References 67 publications

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“…The significant increase in the oxygen (O) percentage is a very strong indicator of successful PEG chain tethering to the DSC activated PEG grafted surface. Comparative elemental composition (%) studies of oxygen (O) among the Nylon 6-NH and modified samples with other PEG derivatives exhibited similar results in our previous work [ 20 ]. Furthermore, the immobilization was confirmed by FT-IR spectroscopy.…”

Section: Resultssupporting

confidence: 78%

“…The second sample (Nylon 6-NH) exhibited less green fluorescence along with a few red dots ( Figure 7 b) compare to the first sample. The image analysis significantly confirms the decrease in the attachment of viable P. aeruginosa bacterial cells to the surface of the reduced sample compares to the unmodified sample [ 20 ]. The Nylon 6-N-PEG sample seems to have the best antifouling properties against P. aeruginosa comparing to the previous two samples ( Figure 7 c).…”

Section: Resultsmentioning

confidence: 82%

“…Wide scientific studies have reported that an FSE of between 23 and 30 mJ/m 2 is related to the lowest bacterial adhesion [ 38 ]. In our previous work, we exhibited the remarkable antibacterial property of the Nylon 6-NH surface and the FSE may have been one of the significant factors [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…The biomedical industry widely utilizes polyamides, including Nylon 6, for various purposes such as wound dressings, suture material, dialysis membranes, catheters, angioplasty balloons and porous bone scaffolds, etc. [ 20 ]. The recent worldwide crisis due to novel COVID-19 has enhanced the importance of polymers for producing effective personal protective equipment (PPE) to create a barrier between humans and germs.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous studies, we explored various different ways of modifying the surface of Nylon 6 to alter the surface functional groups to graft PEG derivatives via chemical modification [ 20 , 34 ]. Our recent studies were chiefly focused on the efficient immobilization of PEG chains on a reduced Nylon 6 surface using a conjugation reaction with the carbonyl group of DSC.…”

Section: Introductionmentioning

confidence: 99%

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The Covalent Tethering of Poly(ethylene glycol) to Nylon 6 Surface via N,N′-Disuccinimidyl Carbonate Conjugation: A New Approach in the Fight against Pathogenic Bacteria

2020

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Different forms of unmodified and modified Poly(ethylene glycols) (PEGs) are widely used as antifouling and antibacterial agents for biomedical industries and Nylon 6 is one of the polymers used for biomedical textiles. Our recent study focused on an efficient approach to PEG immobilization on a reduced Nylon 6 surface via N,N′–disuccinimidyl carbonate (DSC) conjugation. The conversion of amide functional groups to secondary amines on the Nylon 6 polymer surface was achieved by the reducing agent borane-tetrahydrofuran (BH3–THF) complex, before binding the PEG. Various techniques, including water contact angle and free surface energy measurements, atomic force microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy, were used to confirm the desired surface immobilization. Our findings indicated that PEG may be efficiently tethered to the Nylon 6 surface via DSC, having an enormous future potential for antifouling biomedical materials. The bacterial adhesion performances against S. aureus and P. aeruginosa were examined. In vitro cytocompatibility was successfully tested on pure, reduced, and PEG immobilized samples.

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Section: Resultssupporting

confidence: 78%

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Covalent Tethering of Poly(ethylene glycol) to Nylon 6 Surface via N,N′-Disuccinimidyl Carbonate Conjugation: A New Approach in the Fight against Pathogenic Bacteria

2020

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Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

Zhan,

Hu,

et al. 2024

J Biomedical Materials Res

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Pseudomonas aeruginosa (PA) is a widely prevalent opportunistic pathogen. Multiple resistant strains of PA have emerged from excessive or inappropriate use of antibiotics, making their eradication increasingly difficult. Therefore, the search for highly efficient and secure novel antimicrobial agents is crucial. According to reports, there is an increasing exploration of nanometals for antibacterial purposes. The antibacterial mechanisms involving the nanomaterials themselves, the release of ions, and the induced oxidative stress causing leakage and damage to biomolecules are widely accepted. Additionally, the study of the cytotoxicity of metal nanoparticles is crucial for their antibacterial applications. This article summarizes the types of metal nanomaterials and metal oxide nanomaterials that can be used against PA, their respective unique antibacterial mechanisms, cytotoxicity, and efforts made to improve antibacterial performance and reduce toxicity, including combination therapy with other materials and antibiotics, as well as green synthesis approaches.

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Anti-adhesive activity of some secondary metabolites against Staphylococcus aureus on 3D printing medical materials

et al. 2023

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Recent improvements in 3D printing technology have increased the usage of 3D printed materials in several area. An exciting and emerging area of applying these next-generation manufacturing strategies is in the development of devices for biomedical applications.The main aim of this work was to investigate the effect of tannic acid, gallic acid and epicatechin gallate on the physicochemical characteristics of Acrylonitrile Butadiene-Styrene (ABS) and Nylon 3D printing materials. The results of the contact angle measurements showed a signi cant change in the physicochemical properties of both surfaces, indicated an increase in electron donor character of 3D printing materials following treatment. Thus, the ABS surfaces treated with tannic acid, gallic acid and epicatechin gallate have become more electron donating. Furthermore, the adhesion of Staphylococcus aureus on untreated and treated materials was evaluated by the scanning electron microscopy (SEM) analysis and the images were treated by MATLAB software. Our results proved the ability of S. aureus to adhere on all materials with a percentage of 77.86% for ABS and 91.62% for Nylon. The SEM has shown that all actives molecules were su cient to obtain better inhibition of bacterial adhesion, which tannic acid has showed a total inhibition of S. aureus on ABS.

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A comparative study between chemically modified and copper nanoparticle immobilized Nylon 6 films to explore their efficiency in fighting against two types of pathogenic bacteria

Cited by 14 publications

References 67 publications

The Covalent Tethering of Poly(ethylene glycol) to Nylon 6 Surface via N,N′-Disuccinimidyl Carbonate Conjugation: A New Approach in the Fight against Pathogenic Bacteria

The Covalent Tethering of Poly(ethylene glycol) to Nylon 6 Surface via N,N′-Disuccinimidyl Carbonate Conjugation: A New Approach in the Fight against Pathogenic Bacteria

Therapeutic strategies for drug‐resistant Pseudomonas aeruginosa: Metal and metal oxide nanoparticles

Anti-adhesive activity of some secondary metabolites against Staphylococcus aureus on 3D printing medical materials

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