A Comparative Study Between Corresponding Structural Geometric Variables Using 2 Commonly Implemented Hip Structural Analysis Algorithms Applied to Dual-Energy X-Ray Absorptiometry Images

Khoo, Benjamin; Wilson, Scott G.; Worth, Graeme K.; Perks, Ursula; Qweitin, Emad; Spector, Timothy D.; Price, Roger I.

doi:10.1016/j.jocd.2009.08.004

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…There are inherent limitations in attempts to assess three‐dimensional structure from two‐dimensional images. Two‐dimensional DXA structural geometrical variables dependent on mass calibration standards and mathematical derivation techniques are different from three‐dimensional QCT variables . However, correlations between measured variables between DXA and QCT range from moderate to high (0.73 to 0.90), substantiating the assumptions underlying the HSA approach and increasing confidence that 2D HSA replicates the 3D measures .…”

Section: Discussionmentioning

confidence: 86%

Does Hormone Replacement Normalize Bone Geometry in Adolescents With Anorexia Nervosa?

DiVasta

Feldman

Beck³

et al. 2013

Journal of Bone and Mineral Research

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Young women with anorexia nervosa (AN) have reduced secretion of dehydroepiandrosterone (DHEA) and estrogen contributing to skeletal deficits. In this randomized, placebo-controlled trial, we investigated the effects of oral DHEA+ combined oral contraceptive (COC) vs. placebo on changes in bone geometry in young women with AN. Eighty women with AN, aged 13-27 yr, received a random, double-blinded assignment to micronized DHEA (50 mg/d) + COC (20μg ethinyl estradiol/0.1mg levonorgestrel) or placebo for 18 mo. Measurements of aBMD at the total hip were obtained by dual-energy X-ray absorptiometry at 0, 6, 12, and 18 mo. We used the Hip Structural Analysis (HSA) Program to determine BMD, cross-sectional area (CSA), and section modulus at the femoral neck and shaft. Each measurement was expressed as a percentage of the age-, height-, and lean mass-specific mean from an independent sample of healthy adolescent females. Over the 18 months, DHEA+COC led to stabilization in femoral shaft BMD (0.0 ± 0.5 % of normal mean for age, height, and lean mass/year) compared with decreases in the placebo group (−1.1 ± 0.5% per year, p=0.03). Similarly, CSA, section modulus, and cortical thickness improved with treatment. In young women with AN, adrenal and gonadal hormone replacement improved bone health and increased cross sectional geometry. Our results indicate that this combination treatment has a beneficial impact on surrogate measures of bone strength, and not only bone density, in young women with AN.

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Section: Discussionmentioning

confidence: 86%

Does Hormone Replacement Normalize Bone Geometry in Adolescents With Anorexia Nervosa?

DiVasta

Feldman

Beck³

et al. 2013

Journal of Bone and Mineral Research

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“…The Hologic version of HSA and the HSA software provided by Prof. Beck for various research studies have been shown to be highly correlated by Khoo et.al. [16] in an independent study utilizing a fan beam Hologic densitometer equivalent to the one used in this study.…”

Section: Methodsmentioning

confidence: 99%

An in vivo comparison of hip structure analysis (HSA) with measurements obtained by QCT

Ramamurthi

Ahmad

Engelke³

et al. 2011

Osteoporos Int

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SummaryIn a population of elderly women, bone cross-sectional area (CSA), cross-sectional moment of inertia (CSMI), section modulus (Z), femoral neck axis length (FNAL), and width measured with hip structure analysis (HSA) on dual-energy x-ray absorptiometry (DXA) images in the femoral neck and trochanteric regions are highly correlated to quantitative computed tomography (QCT) measurements.IntroductionHSA is a method of obtaining measurements of proximal femur structure using 2D DXA technology. This study was designed to examine the correlations between HSA measurements and 3D QCT.MethodsForty-one women (mean age, 82.8 ± 2.5 years) were measured using DXA and a 64-slice CT scanner (1 mm slice thickness, 0.29 mm in plane resolution). HSA parameters were calculated at the narrow neck (NN) and trochanteric (IT) regions on the DXA image. These regions were then translated to anatomically equivalent regions on the QCT dataset by co-registering the DXA image and QCT dataset using four DXA images acquired at different angles.ResultsAt the NN and IT regions, high linear correlations were measured between HSA and QCT for CSA r = 0.95 and 0.93, CSMI r = 0.94 and 0.93, and Z r = 0.93 and 0.89, respectively. All correlations were highly significant (p < 0.001), but there were differences in slope and offset between the two techniques, at least in part due to differences in calibration between the two techniques. FNAL and width of the bone at the NN and IT regions, physical measurements independent of the calibration, were highly correlated (r = 0.90–0.95, p < 0.001) and had slopes close to 1.0 (range, 0.978 to 1.003).ConclusionCSA, CSMI, Z, FNAL, and width measured by HSA correlate highly to high-resolution QCT.

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“…At the narrow neck of the proximal femur, APEX 3 utilises a tubular model with a 0.6 cortical to trabecular ratio [8,9]. In a previous study [10], good correlations (R>0.8) were seen between HSA calculated with APEX and HSA calculated by the program provided by Prof. Thomas Beck of the Johns Hopkins University.…”

Section: Subjectsmentioning

confidence: 98%

Differences in structural geometrical outcomes at the neck of the proximal femur using two-dimensional DXA-derived projection (APEX) and three-dimensional QCT-derived (BIT QCT) techniques

et al. 2011

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A Comparative Study Between Corresponding Structural Geometric Variables Using 2 Commonly Implemented Hip Structural Analysis Algorithms Applied to Dual-Energy X-Ray Absorptiometry Images

Cited by 6 publications

References 17 publications

Does Hormone Replacement Normalize Bone Geometry in Adolescents With Anorexia Nervosa?

Does Hormone Replacement Normalize Bone Geometry in Adolescents With Anorexia Nervosa?

An in vivo comparison of hip structure analysis (HSA) with measurements obtained by QCT

Differences in structural geometrical outcomes at the neck of the proximal femur using two-dimensional DXA-derived projection (APEX) and three-dimensional QCT-derived (BIT QCT) techniques

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