A Comparative Study between Ginger and Echinacea Possible Effect on the Albino Rat Spleen of Experimentally Induced Diabetes

Said, Hoda M.; Abdel-Aziz, Hekmat Osman; Elhaliem, Nesreen G. Abd; Elsherif, Sherine Ahmed

doi:10.21608/ejh.2019.16107.1156

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…In the current study, lung of diabetic rats treated with echinacea had a significant decrease in the area percentage of collagen fibers compared to diabetic rats. In agreement with this finding, researchers reported that echinacea decreased collagen accumulation in the spleen of diabetic rats [27] . Other study reported that echinacea reduced accumulation of collagen and elastin caused by testicular toxicity by magnetic nanoparticles [28] .…”

Section: Discussionsupporting

confidence: 73%

“…Other study also reported that echinacea decreased apoptotic cells in the spleen of diabetic rats [27] . It could be attributed to the antioxidant effect of echinacea or its ameliorative effect in hyperglycemia.…”

Section: Discussionmentioning

confidence: 78%

“…These results are in agreement with previous studies. They found an increase in the content of collagen fibers in both lung and spleen of diabetic rats [27] . Studies reported that hyperglycemia leads to non-enzymatic glycosylation of proteins in the lungs and chest wall that causes the collagen less liable to proteolysis.…”

Section: Discussionmentioning

confidence: 96%

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The Possible Protective Role of Echinacea and Ginger and both of them on the Lung of Diabetic Male Rats: Histological and Immunohistochemical Study

Ahmed

Abdel-Aziz

Elsayed

et al. 2021

Egyptian Journal of Histology

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Introduction:Diabetes is a systemic disease characterized by a state of hyperglycemia. Several changes in the respiratory functions had been detected in diabetic patients. Aim of the Work:The current study estimated the efficiency of two herbal extract (ginger and echinacea) on the changes in the lung of diabetic animal model. Materials and Methods: 50 adult male albino rats were used. They were divided into five groups. Control group (group I) received regular diet. Group II: diabetic group (diabetes induced by a single intraperitoneal injection of streptozotocin 60 mg/ kg). Group III: diabetic rats treated with 100mg/kg echinacea orally for 30 days. Group IV: diabetic rats treated with 400mg/kg ginger orally for 30 days. Group V: diabetic rats treated with both 100mg/kg echinacea and 400mg/kg ginger orally for 30 days. Paraffin blocks were prepared for histological and immunohistochemical examinations. Morphometric study and statistical analysis were done for the thickness of the interalveolar septum, the area percentage of collagen fibers and number of positive caspase -3 cells and CD68 positive macrophages. Ultrathin sections were prepared for electron microscopic examination. Results: Diabetes caused a significant increase in the thickness of the interalveolar septa, the area percentage of collagen fibers, the number of caspase-3 positive cells as well as the number of CD68 positive alveolar macrophages compared to the control group. Ultrastructurally, pneumocyte type II appeared with denser nucleus, numerous vacuoles and disorganized lamellar bodies. Conclusion: Groups treated with echinacea or ginger or both showed a significant decrease in the thickness of the interalveolar septa, the area percentage of collagen fibers, the number of caspase-3 positive cells as well as the number of CD68 positive alveolar macrophages compared to the diabetic group. These groups also showed that pneumocyte type II restored their normal appearance.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 78%

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The Possible Protective Role of Echinacea and Ginger and both of them on the Lung of Diabetic Male Rats: Histological and Immunohistochemical Study

Ahmed

Abdel-Aziz

Elsayed

et al. 2021

Egyptian Journal of Histology

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“…Ginger (Zingiber officinale Roscoe), a herbal plant from the Zingiberaceae family, is one of those plants. It has been used as spice and medicine for treating cancer [1]; cardiovascular disease [2]; diabetes [3]; and several other illnesses such as cold, nausea, asthma, and cough [4]. Owing to the global pandemic of COVID-19, ginger consumption gained more interest.…”

Section: Introductionmentioning

confidence: 99%

Micropropagation of Ginger (Zingiber officinale Roscoe) ‘Bentong’ and Evaluation of Its Secondary Metabolites and Antioxidant Activities Compared with the Conventionally Propagated Plant

Zahid

Jaafar

Hakiman

2021

Plants

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‘Bentong’ ginger is the most popular variety of Zingiber officinale in Malaysia. It is vegetatively propagated and requires a high proportion of rhizomes as starting planting materials. Besides, ginger vegetative propagation using its rhizomes is accompanied by several types of soil-borne diseases. Plant tissue culture techniques have been applied in many plant species to produce their disease-free planting materials. As ‘Bentong’ ginger is less known for its micropropagation, this study was conducted to investigate the effects of Clorox (5.25% sodium hypochlorite (NaOCl)) on explant surface sterilization, effects of plant growth regulators, and basal media on shoots’ multiplication and rooting. The secondary metabolites and antioxidant activities of the micropropagated plants were evaluated in comparison with conventionally propagated plants. Rhizome sprouted buds were effectively sterilized in 70% Clorox for 30 min by obtaining 75% contamination-free explants. Murashige and Skoog (MS) supplemented with 10 µM of zeatin was the suitable medium for shoot multiplication, which resulted in the highest number of shoots per explant (4.28). MS medium supplemented with 7.5 µM 1-naphthaleneacetic acid (NAA) resulted in the highest number of roots per plantlet. The in vitro-rooted plantlets were successfully acclimatized with a 95% survival rate in the ex vitro conditions. The phytochemical analysis showed that total phenolic acid and total flavonoid content and antioxidant activities of the micropropagated plants were not significantly different from the conventionally propagated plants of ‘Bentong’ ginger. In conclusion, the present study’s outcome can be adopted for large-scale propagation of disease-free planting materials of ‘Bentong’ ginger.

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The Possible Ameliorative Effect of Echinacea, Ginger, and Their Combination on Experimentally Induced Diabetic Nephropathy in a Rat Model: Histological and Immunohistochemical Study

Mohammed¹,

El‐Sayed²,

Abdel-Aziz³

et al. 2023

Journal of Microscopy and Ultrastructure

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Background: Diabetes represents a chronic disease characterized by hyperglycemia. Several changes in the renal functions had been detected in diabetic patients. Aim of the Work: This study was conducted to compare the possible ameliorative role of both ginger and Echinacea either alone or in combination upon experimentally induced diabetic nephropathy. Materials and Methods: Sixty adult male albino rats were used in this study. Rats were divided into three groups. Control (group I) included 20 rats. Diabetic group (group II) included 10 rats. Group III included 30 rats subdivided into three subgroups 10 animals each: Subgroup IIIa diabetic treated with 100 mg/kg Echinacea for 30 days. Subgroup IIIb diabetic treated with 400 mg/kg ginger for 30 days orally. Subgroup IIIc diabetic treated with both 100 mg/kg Echinacea and 400 mg/kg ginger for 30 days orally. Hemotoxylin and eosin staining, Periodic acid Schiff and Masson trichrome were done. Ultrastructural examination was done. Immunohistochemical markers used were caspase-3 for apoptosis and CD68 for macrophages. Morphometric and statistical analyses were done. Results: Diabetes caused a significant increase in collagen fibers in the renal cortex, the caspase-3 expression as well as the number of macrophages. Ultrastructurally, there was an irregularly thickened glomerular basement membrane and effacement of podocytes. Ginger treatment alone or in combination with Echinacea exhibited more pronounced improvement of diabetes-induced degenerative changes and a significant decrease in collagen fibers, the caspase-3 expression as well as the number of macrophages compared to Echinacea alone. Conclusion: Ginger treatment alone or in combination with Echinacea exhibited more pronounced improvement in diabetes nephropathy.

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A Comparative Study between Ginger and Echinacea Possible Effect on the Albino Rat Spleen of Experimentally Induced Diabetes

Cited by 4 publications

References 34 publications

The Possible Protective Role of Echinacea and Ginger and both of them on the Lung of Diabetic Male Rats: Histological and Immunohistochemical Study

The Possible Protective Role of Echinacea and Ginger and both of them on the Lung of Diabetic Male Rats: Histological and Immunohistochemical Study

Micropropagation of Ginger (Zingiber officinale Roscoe) ‘Bentong’ and Evaluation of Its Secondary Metabolites and Antioxidant Activities Compared with the Conventionally Propagated Plant

The Possible Ameliorative Effect of Echinacea, Ginger, and Their Combination on Experimentally Induced Diabetic Nephropathy in a Rat Model: Histological and Immunohistochemical Study

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