A Comparative Study Between the Effect of Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants (A Randomized Clinical Trial)

Abstract

INTRODUCTION:A lot of studies covered the use of growth factor-containing products as enhancers of osseointegration. Concentrated growth factors or CGF is a third generation platelet concentrate that is used to improve osseointegration of implants. AIM OF THE STUDY: to compare the effect of CGF on implant stability, bone density, and the horizontal dimension of the bone adjacent to the implant to that of platelet rich fibrin (PRF). MATERIAL AND METHODS: Fourteen participants with mandibular premolars that needed extraction and replaced immediately were assigned into two groups; a study group and a control group. A CGF membrane was laid in the implant osteotomies of the study group while a platelet-rich fibrin (PRF) membrane was placed in the osteotomies of the control group. The space in between the socket and the implant was filled with bone graft. To assess implant stability, a resonance frequency analysis (RFA) was performed immediately. After one week and after three months, a follow-up RFA was conducted. Preoperatively, directly after surgery, and three months afterwards, cone beam computed tomography (CBCT) was performed. RESULTS: Implant stability and bone density improved significantly in both groups after three months with no significant change in the horizontal dimension of bone for both groups. While higher implant stability and bone density readings were recorded in the CGF group, there was no change between the two groups that had statistical significance. CONCLUSION: CGF enhances osseointegration more than PRF when evaluated radiographically and with resonance frequency analysis but with no statistical significance.