A comparative study between the values of lecithin, sphingomyelin, lysolecithin, the L/S Index, and the CLEMENTS test in amniotic fluid

Cabero, L.; Carreras, Marı́a Cecilia; Viscasillas, P.; Roses, A. D.; Grau, V; Durán-Sánchez, P.; Massanas, J.; Esteban-Altirriba, J.

doi:10.1515/jpme.1976.4.2.111

Journal of Perinatal Medicine

1976

DOI: 10.1515/jpme.1976.4.2.111

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A comparative study between the values of lecithin, sphingomyelin, lysolecithin, the L/S Index, and the CLEMENTS test in amniotic fluid

L. Cabero¹,

Marı́a Cecilia Carreras²,

P. Viscasillas³

et al.

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1982

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Methods of Evaluating Fetal Lung Maturity

Brown

Duck-Chong

1982

CRC Critical Reviews in Clinical Laboratory Sciences

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Respiratory distress syndrome occurs in infants born with immature lungs. The immature fetal lung lacks an adequate supply of surfactant, a phospholipid-rich substance which is produced in the type II cells of the alveolar epithelium. In the fetus, surfactant is secreted into the potential air spaces of the lung and passes into the amniotic fluid as gestation proceeds. It is now clear that most methods currently in use for assessing fetal lung maturity depend on the detection of a sudden release of surfactant into the amniotic fluid as the lung reaches a critical stage of maturity. These methods, which include the lecithin/sphingomyelin ratio, the lung profile, total phospholipid or lecithin concentration, fluorescence depolarization, lamellar body phospholipid concentration, and the "shake" test, are reviewed in the light of recent understanding of the nature of surfactant. In assessing each method, we have examined possible sources of error in performing the test in the laboratory, factors which could theoretically limit its ability to reflect the state of fetal lung maturity and current information regarding its reliability, in terms of clinical performance. Guidelines for future research in this area are also suggested.

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Methods of Evaluating Fetal Lung Maturity

Brown

Duck-Chong

1982

CRC Critical Reviews in Clinical Laboratory Sciences

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A comparative study between the values of lecithin, sphingomyelin, lysolecithin, the L/S Index, and the CLEMENTS test in amniotic fluid

Cited by 1 publication

References 16 publications

Methods of Evaluating Fetal Lung Maturity

Methods of Evaluating Fetal Lung Maturity

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