Background
Offloading interventions are commonly used in clinical practice to heal foot ulcers. The aim of this updated systematic review is to investigate the effectiveness of offloading interventions to heal diabetic foot ulcers.
Methods
We updated our previous systematic review search of PubMed, EMBASE, and Cochrane databases to also include original studies published between July 29, 2014 and August 13, 2018 relating to four offloading intervention categories in populations with diabetic foot ulcers: (a) offloading devices, (b) footwear, (c) other offloading techniques, and (d) surgical offloading techniques. Outcomes included ulcer healing, plantar pressure, ambulatory activity, adherence, adverse events, patientâreported measures, and costâeffectiveness. Included controlled studies were assessed for methodological quality and had key data extracted into evidence and risk of bias tables. Included nonâcontrolled studies were summarised on a narrative basis.
Results
We identified 41 studies from our updated search for a total of 165 included studies. Six included studies were metaâanalyses, 26 randomised controlled trials (RCTs), 13 other controlled studies, and 120 nonâcontrolled studies. Five metaâanalyses and 12 RCTs provided highâquality evidence for nonâremovable kneeâhigh offloading devices being more effective than removable offloading devices and therapeutic footwear for healing plantar forefoot and midfoot ulcers. Total contact casts (TCCs) and nonâremovable kneeâhigh walkers were shown to be equally effective. Moderateâquality evidence exists for removable kneeâhigh and ankleâhigh offloading devices being equally effective in healing, but kneeâhigh devices have a larger effect on reducing plantar pressure and ambulatory activity. Lowâquality evidence exists for the use of felted foam and surgical offloading to promote healing of plantar forefoot and midfoot ulcers. Very limited evidence exists for the efficacy of any offloading intervention for healing plantar heel ulcers, nonâplantar ulcers, and neuropathic ulcers with infection or ischemia.
Conclusion
Strong evidence supports the use of nonâremovable kneeâhigh offloading devices (either TCC or nonâremovable walker) as the firstâchoice offloading intervention for healing plantar neuropathic forefoot and midfoot ulcers. Removable offloading devices, either kneeâhigh or ankleâhigh, are preferred as second choice over other offloading interventions. The evidence bases to support any other offloading intervention is still weak and more highâquality controlled studies are needed in these areas.