A comparative study evaluating the efficacy of IS_MAP04 with IS900 and IS_MAP02 as a new diagnostic target for the detection of Mycobacterium avium subspecies paratuberculosis from bovine faeces

Kruijf, Marcel de; Govender, Rodney; Yearsley, Dermot; Coffey, Aidan; O’Mahony, Jim

doi:10.1016/j.vetmic.2017.04.020

Cited by 5 publications

(1 citation statement)

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“…The isolation of MAP from clinical samples, such as feces, tissue, milk, and blood, has been considered the gold standard for the diagnosis of paratuberculosis (Collins, 2011). Additionally, PCR assays have been developed to detect MAP in feces, and ELISA has been used to detect antibodies against MAP in the host animal (Arango-Sabogal et al, 2016;Gilardoni et al, 2016;de Kruijf et al, 2017;Mathevon et al, 2017). However, those methods have low sensitivity and specificity for the detection of MAP in subclinical infection (Sockett et al, 1992;Cousins et al, 1999;Englund et al, 2002;Bögli-Stuber et al, 2005;Nielsen and Toft, 2008;Collins, 2011).…”

Section: Paratuberculosismentioning

confidence: 99%

Biomarkers as diagnostic tools for mycobacterial infections in cattle

Park

Yoo

2020

Anim. Health. Res. Rev.

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Mycobacterial infections are widely distributed in animals and cause considerable economic losses, especially in livestock animals. Bovine paratuberculosis and bovine tuberculosis, which are representative mycobacterial infections in cattle, are difficult to diagnose using current-generation diagnostics due to their relatively long incubation periods. Thus, alternative diagnostic tools are needed for the detection of mycobacterial infections in cattle. A biomarker is an indicator present in biological fluids that reflects the biological state of an individual during the progression of a specific disease. Therefore, biomarkers are considered a potential diagnostic tool for various diseases. Recently, the number of studies investigating biomarkers as tools for diagnosing mycobacterial infections has increased. In human medicine, many diagnostic biomarkers have been developed and applied in clinical practice. In veterinary medicine, however, many such developments are still in the early stages. In this review, we summarize the current progress in biomarker research related to the development of diagnostic biomarkers for mycobacterial infections in cattle.

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