A comparative study in vitro of physiological activity of triterpene glycosides of marine invertebrates of echinoderm type

Кузнецова, Т. А.; Anisimov, M. M.; Popov, Alexander; Baranova, S.I.; Afiyatullov, Sh. Sh.; Kapustina, I. I.; Antonov, Alexander S.; Elyakov, G. B.

doi:10.1016/0306-4492(82)90165-4

Cited by 29 publications

(19 citation statements)

References 7 publications

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“…The lack of activity of the extracts against bacterial species was clear and supports the findings of previous studies (Shimada 1969;Kuznetsova et al 1982). The activity of the extracts was thus limited to eukaryotic cell types.…”

Section: Bioactivitysupporting

confidence: 90%

Bioactivity as an Options Value of Sea Cucumbers in the Egyptian Red Sea

Lawrence

Khattab

Ahmed

et al. 2010

Conservation Biology

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The utility of a species can be divided into its direct, indirect, and options values. In the marine environment, direct consumptive values predominate and often lead to overexploitation at the expense of significant options values derived through bioprospecting for natural products. We surveyed the waters of the Egyptian Red Sea coast (Gulf of Aqaba [north] and the Red Sea [south]) for species of sea cucumbers and analyzed extracts from species for a range of bioactivities with potential biomedical applications. All habitat types were surveyed within these regions. We found 22 species of sea cucumber of which two, Holothuria fuscogilva and Holothuria flavomaculata, were recorded in Egypt for the first time. Although none of the species identified were unique to the Gulf of Aqaba, 10 species were only found in the Red Sea sector. Bioassay results showed that although no species had antibacterial activity, most extracts exhibited activity against Candida and Leishmania but were most active against a LoVo mammalian carcinoma cell line. Our most significant finding was the intraspecific variation in bioactivity in individuals collected from different habitat types and sectors of the coast. This variation may reflect the effect of environment on secondary metabolite production or may indicate significant genetic diversity between populations within a species. Our results indicate a potentially significant options value to sea cucumbers through bioprospecting. Given the importance of economic development in countries such as Egypt and the perceived low conservation value of invertebrates such as sea cucumbers, the linking of these factors to conservation is vital for the maintenance and sustainable exploitation of these animals.

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Section: Bioactivitysupporting

confidence: 90%

Bioactivity as an Options Value of Sea Cucumbers in the Egyptian Red Sea

Lawrence

Khattab

Ahmed

et al. 2010

Conservation Biology

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“…The stereochemistry of the saponin related to chain composition and length appears to be very important in conferring activity on the saponin molecule [21]. As number of the monosaccharide units attached to the hydroxyl group at C-3 on the aglycone [23] increases up to four to six sugar units, hemolytic activity increases [24]. Also, hemolytic activity of saponins increases with decreasing numbers of polar groups on the aglycone moiety [25].…”

Section: Resultsmentioning

confidence: 99%

Hemolytic and Antimicrobial Activities Differ Among Saponin-rich Extracts From Guar, Quillaja, Yucca, and Soybean

Hassan

Byrd²,

Cartwright

et al. 2009

Appl Biochem Biotechnol

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Hemolytic and antibacterial activities of eight serial concentrations ranged from 5-666 microg/mL of saponin-rich extracts from guar meal (GM), quillaja, yucca, and soybean were tested in 96-well plates and read by enzyme-linked immunosorbent assay plate-well as 650 nm. Hemolytic assay used a 1% suspension of chicken red blood cells with water and phosphate buffered saline as positive and negative controls, respectively. Antibacterial activity against Staphylococcus aureus, Salmonella typhimurium, and Escherichia coli were evaluated using ampicillin and bacteria without saponin-rich extract as positive and negative controls, respectively. The 100% MeOH GM and commercial quillaja saponin-rich extracts were significantly the highest in both hemolytic and antibacterial activities against all bacteria at the same concentration tested. Soybean saponin-rich extract had no antibacterial activity against any of the bacteria at the concentrations tested while yucca saponin-rich extract had no antibacterial activity against the gram-negative bacteria at the concentrations tested. GM and quillaja saponin-rich extracts were hemolytic, while yucca and soybean saponin-rich extracts were not hemolytic at the concentrations tested. No saponin-rich extract source had antibacterial activity against S. typhimurium or E. coli at the concentrations tested. Both GM and quillaja saponin-rich extracts exhibited antibacterial activity against S. aureus. Saponin-rich extracts from different plant sources have different hemolytic and antibacterial activities.

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“…It has been reported that the tegument of some species of sea cucumber contains a substance called holothurin which has anti-tumor and antifungal activities (Anisimov et al, 1980 ;Kuznetsova et al, 1982), as well as an anti-bacterial effect (Ridzwan et al,1995 ;Noah et al, 2001). Therefore, the absence of such pathogens from the present sea…”

Section: Discussionmentioning

confidence: 99%

An Investigation on Pathogenic Micro - Organisms of Paracentrotus Lividus and Holothuria Polii (Echinodermata) Mediterranean Sea Egypt.

Omran

Eissa

2006

Egypt. J. of Aquatic Biolo. and Fish.

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ABSTRACTicrobiological studies of two echinoderms, the Sea Urchin, Paracentrotus lividus and the Sea cucumber, Holothuria polii from Abu-Qir region of Alexandria Mediterranean coast, were conducted during July 2005. The isolates revealed Gram-positive bacteria from the gonads of the sea urchin and two types of pathogenic fungi from its digestive tract. On the other hand, no isolates were detected from the sea cucumber. The effect of the isolated microorganisms was discussed.

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A comparative study in vitro of physiological activity of triterpene glycosides of marine invertebrates of echinoderm type

Cited by 29 publications

References 7 publications

Bioactivity as an Options Value of Sea Cucumbers in the Egyptian Red Sea

Bioactivity as an Options Value of Sea Cucumbers in the Egyptian Red Sea

Hemolytic and Antimicrobial Activities Differ Among Saponin-rich Extracts From Guar, Quillaja, Yucca, and Soybean

An Investigation on Pathogenic Micro - Organisms of Paracentrotus Lividus and Holothuria Polii (Echinodermata) Mediterranean Sea Egypt.

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