A comparative study of AML, NEGML and OSEM based on experimental and clinical <sup>90</sup>Y-PET data using the CASToR platform

Millardet, Maël; Moussaoui, Saïd; Mateus, Diana; Idier, Jérôme; Conti, Maurizio; Carlier, Thomas

doi:10.1109/nssmic.2018.8824361

Cited by 1 publication

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“…8, 16, 32 iterations with 8 subsets with and without scatter correction were chosen as parameters for reconstruction. CASTOR was used for reconstructing all simulated projections which is based on OSEM [31,32].…”

Section: Reconstruction and Correctionsmentioning

confidence: 99%

Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study

Oral

Güveniş

2021

Biomed. Phys. Eng. Express

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Objective. SPECT-CT is a standard procedure conducted before minimally invasive surgery for the treatment of primary hyperthyroidism. In order to improve image quality, it is important to know how defect detectability is influenced by acquisition and processing parameters. The objective of this study is to continue prior physical phantom optimization studies by performing Monte Carlo simulations for the dual phase parathyroid SPECT-CT protocol using a digital anthropomorphic phantom. Methods. The dual phase parathyroid SPECT-CT imaging procedure with 99mTc-Sestamibi was simulated using the previously extensively validated SIMIND software for the first time. An anthropomorphic ZUBAL based phantom was built to represent an adenoma. Its diameter was set to 0.76 cm which corresponded to more than three times the pixel size and the target-to-background ratio was set to 16:1 based on previous studies. Four different collimators were tested. Contrast-tonoise (CNR) values were determined for different scatter correction options and processing parameter values. The OSEM algorithm was used for image reconstruction. Results. CNR values were improved from about zero (LEGP collimator, 16 iterations, attenuation correction: on, scatter correction: off) up to 3.7 (LEUHR collimator, 16 iterations, attenuation correction: on, scatter correction: off). The subjective visual assessment of detectability on simulated images agreed with the quantitative CNR values. Conclusion. Higher resolution collimators gave better CNR as confirmed by similar studies. The effect of scatter correction was found beneficial only if both the resolution and sensitivity of the collimator were relatively high. This is a significant finding since there is a shortage of definitive guideline on the use of scatter correction for parathyroid SPECT imaging.

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Section: Reconstruction and Correctionsmentioning

confidence: 99%

Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study

Oral

Güveniş

2021

Biomed. Phys. Eng. Express

View full text Add to dashboard Cite

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A comparative study of AML, NEGML and OSEM based on experimental and clinical ⁹⁰Y-PET data using the CASToR platform

Cited by 1 publication

References 6 publications

Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study

Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study

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A comparative study of AML, NEGML and OSEM based on experimental and clinical 90Y-PET data using the CASToR platform

Cited by 1 publication

References 6 publications

Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study

Improving the detectability of overactive glands in dual-phase parathyroid SPECT/CT: a Monte Carlo simulation study

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A comparative study of AML, NEGML and OSEM based on experimental and clinical ⁹⁰Y-PET data using the CASToR platform