A Comparative Study of Analgesic Activity of Fluoxetine With Ibuprofen and Pentazocine in Rodent Models

Banderao, Patil; Binjawadgi, Ashok; R.H, Kakkeri; Raikar, Shrinivas; Anandi, Basavambika

doi:10.14260/jemds/1128

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Sara et al 16 in their study, mention the advantage of the hot plate test is that, it can be applied repeatedly in the same animals over a short period of time (2-3 h) without causing tissue injury. A study done by Patil et al 17 showed that the test compound fluoxetine, compared with control using the hot plate method, had a statistically significant analgesic activity with p values of < 0.01 and < 0.001 respectively. Pentazocine has also showed the same statistically significant analgesic activity.…”

Section: Fig 1: Anti-inflammatory Activity Of Standard Drug and Test ...mentioning

confidence: 99%

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2023

IJPSR

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The analgesic activity of vilazodone in albino rats and mice was compared with the standard drug pentazocine and diclofenac, and its antiinflammatory activity in albino rats was compared with the standard drug indomethacin. The doses of vilazodone used were 1.8mg/kg and 3.6mg/kg in albino rats and 2.6mg/kg and 5.2 mg/kg in albino mice, and the methods to screen analgesic activities were eddy's hot plate method, tail flick method using radiant heat and acetic acid induced writhing method and formalin-induced peritonitis was used to screen anti-inflammatory activity. The data was analyzed statistically and results were expressed as numbers and percentages. For vilazodone dose of 1.8mg/kg and 3.6mg/kg using eddy's hot plate method mean reaction time were 6.50± 0.288 and 5.70± 0.285, in tail flick method 6.50±0.288 and 6.45± 0.521. In the writhing method at a dose of 2.6mg/kg and 5.2 mg/kg in albino mice vilazodone showed 30.33±1.15 and 28.16±0.98 analgesic activity compared to control. In formalin induced peritonitis vilazodone 1.8mg/kg and 3.6mg/kg showed 2.2±0.13 and 1.86±0.05 anti-inflammatory activity when compared to control. Statistically significant results were obtained with a higher dose in hot plate and tail flick method and with low dose in writhing method when compared to the standard. Vilazodone, compared to standard in formalininduced peritonitis, has shown statistically significant results in both doses. Vilazodone has shown significant analgesic and anti-inflammatory activities.INTRODUCTION: Pain is one of the common health problems with a sensory experience that is multidirectional, intrinsically unpleasant, illdefined, disabling of many medical conditions. According to the International Association for the Study of Pain (IASP), the updated and recent definition of pain is an unpleasant sensory and emotional experience associated with or resembling that associated with, actual or potential tissue damage 1 .

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Section: Fig 1: Anti-inflammatory Activity Of Standard Drug and Test ...mentioning

confidence: 99%

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2023

IJPSR

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Uses of fluoxetine in nociceptive pain management: A literature overview

Barakat

Hamdy

Elbadr

2018

European Journal of Pharmacology

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Overview of Neurological Mechanism of Pain Profile Used for Animal “Pain-Like” Behavioral Study with Proposed Analgesic Pathways

Yam

Loh

et al. 2020

IJMS

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Pain is the most common sensation installed in us naturally which plays a vital role in defending us against severe harm. This neurological mechanism pathway has been one of the most complex and comprehensive topics but there has never been an elaborate justification of the types of analgesics that used to reduce the pain sensation through which specific pathways. Of course, there have been some answers to curbing of pain which is a lifesaver in numerous situations—chronic and acute pain conditions alike. This has been explored by scientists using pain-like behavioral study methodologies in non-anesthetized animals since decades ago to characterize the analgesic profile such as centrally or peripherally acting drugs and allowing for the development of analgesics. However, widely the methodology is being practiced such as the tail flick/Hargreaves test and Von Frey/Randall–Selitto tests which are stimulus-evoked nociception studies, and there has rarely been a complete review of all these methodologies, their benefits and its downside coupled with the mechanism of the action that is involved. Thus, this review solely focused on the complete protocol that is being adapted in each behavioral study methods induced by different phlogogenic agents, the different assessment methods used for phasic, tonic and inflammatory pain studies and the proposed mechanism of action underlying each behavioral study methodology for analgesic drug profiling. It is our belief that this review could significantly provide a concise idea and improve our scientists’ understanding towards pain management in future research.

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A Comparative Study of Analgesic Activity of Fluoxetine With Ibuprofen and Pentazocine in Rodent Models

Cited by 3 publications

References 22 publications

Untitled

Untitled

Uses of fluoxetine in nociceptive pain management: A literature overview

Overview of Neurological Mechanism of Pain Profile Used for Animal “Pain-Like” Behavioral Study with Proposed Analgesic Pathways

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