Activated sludge (AS) process has been used as the conventional industrial wastewater treatment process in the past decades. However, intensive aeration requirements made it impossible for WWTPs to be energy positive. In addition, there are few cases of research assessing the efficiency and economic feasibility of innovative technologies in treating industrial wastewater to achieve energy positive. This study tries to assess the effect of different kinds of industrial wastewater on treatment efficiency, unit energy, environmental sustainability, and unit cost of treatment systems using innovative technologies such as micro sieving, UASB, and PN/A. Our Excel model showed that micro-sieving could remove 32.50-39.72% of COD from industrial wastewater. UASB reactor could removes 15.8%-53.5%, 14.0%-49.0% and 22.9%-51.0% of COD from three different wastewater streams. Mean unit energy production by the innovative system could reach 1.80, 1.77, and 1.73 kWh/kg BODremoved, respectively. The average unit cost of three kinds of wastewater is 0.54, 0.57, and 1.12 $/kg CODremoved, respectively. Treating meat processing wastewater with innovative technologies is the economical treatment method. However, this method could not be considered as the sustainable design due to the high effluent COD concentration. The economic advantages and limitations of innovative technologies in treating industrial wastewater have been quantified by energy, cost and environmental indicators. These metrics provide valuable references for future sustainable design of industrial wastewater treatment systems.