A comparative study of caudal bupivacaine and bupivacaine with clonidine for post-operative analgesia in paediatric patients

Addition of Clonidine or Dexmedetomidine With Bupivacaine to Prolong Caudal Analgesia in Children Undergoing Infraumbilical Surgery

“…On the contrary, Goyal et al [21] found that the incidence of nausea and vomiting was higher in the group receiving plain bupivacaine compared to the group receiving bupivacaine-dexmedetomidine. Meghani et al [23] and Bhatia et al [24] also found that nausea and vomiting were higher in children who received bupivacaine-clonidine than plain bupivacaine.…”

“…In other studies comparing bupivacaine with bupivacaine and dexmedetomidine by Saadawy et al [20], Goyal et al [21], and Goswami et al [19], children in the bupivacaine and dexmedetomidine group had a duration of analgesia significantly longer than bupivacaine alone. Also, in studies comparing bupivacaine with bupivacaine and clonidine, Parameswari et al [18], Hooda [22], Meghani et al [23], Bhatia et al [24], and Rajan et al [25] found that children receiving bupivacaine and clonidine had a significantly longer duration of analgesia than bupivacaine alone.…”

“…Similar to our study, Saadawy et al [20] and Goswami et al [19] found that the mean duration of sedation was significantly prolonged amongst patients belonging to the bupivacaine-dexmedetomidine group compared to patients in the bupivacaine group. Also, Hooda et al [22], Bhatia et al [24], and Meghani et al [23] found that the median sedation score was higher in patients receiving caudal bupivacaine-clonidine compared to those receiving only bupivacaine.…”

“…In other studies by Saadawy et al [20] and Goyal et al [21], they found that children receiving caudal bupivacaine-dexmedetomidine required significantly less dose/s of additional rescue analgesia during the first 12-24 hours postoperatively, compared to children receiving bupivacaine alone. Parameswari et al [18], Meghani et al [23], Bhatia et al [24], and Rajan et al [25] found that the requirement of rescue analgesia for 12-24 hours postoperatively was significantly less in the group receiving bupivacaine-clonidine compared to the group receiving plain bupivacaine.…”