2023
DOI: 10.1016/j.virusres.2023.199053
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A comparative study of COVID-19 transcriptional signatures between clinical samples and preclinical cell models in the search for disease master regulators and drug repositioning candidates

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Cited by 5 publications
(2 citation statements)
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“…Finally, we conducted predictive analysis on the transcriptional regulation mechanisms and potential therapeutic drugs of KCNK12 and hub genes, including MYC [31] ESR1 [32] CTCF [33] SNAI2 [34] JUND [35] is closely related to acute stroke. MYC plays an important role in neuronal repair after ischemia, and JUND regulates IL-1 β Improving cerebral vascular reperfusion injury, ZBTB7A promotes cell survival after coronavirus infection[36], CREB1 identi ed as an important transcription factor in stroke mice [37], MYB is involved in cortical and striatal damage in mouse brain after I/R[38], SP1 has a bidirectional effect in ischemic stroke [39], CBX3 is associated with COVID19 infection [40], TAL1 is considered the main regulatory factor of COVID19 [41], Correlation between TET2 and in ammatory response in ischemic stroke.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, we conducted predictive analysis on the transcriptional regulation mechanisms and potential therapeutic drugs of KCNK12 and hub genes, including MYC [31] ESR1 [32] CTCF [33] SNAI2 [34] JUND [35] is closely related to acute stroke. MYC plays an important role in neuronal repair after ischemia, and JUND regulates IL-1 β Improving cerebral vascular reperfusion injury, ZBTB7A promotes cell survival after coronavirus infection[36], CREB1 identi ed as an important transcription factor in stroke mice [37], MYB is involved in cortical and striatal damage in mouse brain after I/R[38], SP1 has a bidirectional effect in ischemic stroke [39], CBX3 is associated with COVID19 infection [40], TAL1 is considered the main regulatory factor of COVID19 [41], Correlation between TET2 and in ammatory response in ischemic stroke.…”
Section: Discussionmentioning
confidence: 99%
“…According to their study, the expression of KLF2 was reduced in endothelial cells of patients, and thus augmenting KLF2 levels may be therapeutically beneficial. Chapola et al [ 9 ] have identified COVID-19 Master Regulators (MRs) from lung tissues of patients who developed the severe form of the disease. Such MRs include transcription factors such as TAL1, TEAD4, EPAS1, ATOH8, ERG, and ARNTL2.…”
Section: Introductionmentioning
confidence: 99%