A comparative study of disintegration actions of various disintegrants using Kohonen's self-organizing maps

Onuki, Yoshinori; Kosugi, Atsushi; Hamaguchi, Masashi; Marumo, Yuki; Kumada, Shungo; Hirai, Daijiro; Ikeda, Junko; Hayashi, Yoshihiro

doi:10.1016/j.jddst.2017.10.002

Cited by 32 publications

(13 citation statements)

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“…Some studies reported that bound water evaporates with more difficulty than free water because of the restriction of the molecular mobility by the drying process. 29,30) Based on these reports, we investigated the drying efficiency of wet granules after the incubation for 45 min at 50°C. As a result of the experiment, the CS and MCC granules showed more remaining water than the MAN granule, 16%, and 21% respectively (Fig.…”

Section: Dose-dependent Variation In the T 2 Values Of Water Incorpmentioning

confidence: 99%

“…A similar result was obtained in our previous study. 31) In the course of this study, we conducted a comparative study about the disintegration effects of various disintegrants to evaluate the interaction between each disintegrant and water. Suspensions dispersing 10% of disintegrant powders in purified water were prepared, and their T 2 values were examined.…”

Section: Dose-dependent Variation In the T 2 Values Of Water Incorpmentioning

confidence: 99%

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A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

Ito

Okada

Leong

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

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The different states of water incorporated in wet granules were studied by a low-field benchtop 1 H-NMR time-domain NMR (TD-NMR) instrument. Wet granules consisting different fillers [cornstarch (CS), microcrystalline cellulose (MCC), and D-mannitol (MAN)] with different water contents were prepared using a high-speed granulator, and then their spin-spin relaxation time (T 2 ) was measured using the NMR relaxation technique. The experimental T 2 relaxation curves were analyzed by the two-component curve fitting, and then the individual T 2 relaxation behaviors of solid and water in wet granules were identified. According to the observed T 2 values, it was confirmed that the molecular mobility of water in CS and MCC granules was more restricted than that in the MAN granule. The state of water appeared to be associated with the drying efficiency and moisture absorption capacity of wet granules. Thus, it was confirmed that the state of water significantly affected the wet granulation process and the characteristics of the resultant granules. In the final phase of this study, the effects of binders on the molecular mobility of water in granulation fluids and wet granules were examined. The state of water in granulation fluids was substantially changed by changing the binders. The difference was still detected in wet granules prepared by addition of these fluids to the fillers. In conclusion, TD-NMR can offer valuable knowledge on wet granulation from the viewpoint of molecular mobility of water.

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Section: Dose-dependent Variation In the T 2 Values Of Water Incorpmentioning

confidence: 99%

Section: Dose-dependent Variation In the T 2 Values Of Water Incorpmentioning

confidence: 99%

A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

Ito

Okada

Leong

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The results of the present study reveal that SD renders a rapid release of Nifedipine given the reduction in lag time. The addition of SD facilitates the faster contact of the drug with the dissolution medium, which leads to the disintegration of the matrix of the pull layer and enhances the force exerted by the push layer 14,15 . Our results show that CPVP has a greater influence on the release rate than the other SD.…”

Section: Evaluation Of Push-pull Tabletsmentioning

confidence: 99%

“…CPVP is a non-ionic compound that avoids its interaction with cationic and insoluble drugs, such as Nifedipine. The superdisintegrants, CPVP, CS, and SSG, exhibit a wide range of intrinsic swelling properties (SSG>CS>>CPVP), but all of them are effective 14,16 . Furthermore, CPVP exhibits another mechanism for its disintegrative function, namely strain recovery, which sustains that the porosity of tablets creates penetration routes for the fluids in the tablet.…”

Section: Evaluation Of Push-pull Tabletsmentioning

confidence: 99%

“…The amount of water captured by the tablet depends on how hydrophilic the drug/superdisintegrant is and the conditions of the matrix. The functioning of this type of SD requires maintenance of pore structure and low interfacial tension to the aqueous fluids since this helps create a hydrophilic environment surrounding the drug particles 14,16 .…”

Section: Evaluation Of Push-pull Tabletsmentioning

confidence: 99%

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2019

IJPSR

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Push-pull osmotic pumps are controlled drug delivery systems for drugs with a broad range of solubilities; especially drugs that are poorly water-soluble. The aim of the present study was to evaluate the performance of the superdisintegrants (SD), crospovidone (CPVP), croscarmellose sodium (CS), and sodium starch glycolate (SSG), in pushpull tablets containing Nifedipine (NP) as a model drug. We performed an in-vitro dissolution test with phosphate buffer (0.05M) at pH 7.5 for 12 h. The amount of released NP was determined using a UV/Visible spectro-photometric method at a wavelength of 238 nm. At 12 h of release, the profile of CPVP-and CS-containing osmotic tablets was like that of the reference product Adalat OROS ® , whereas the SSG-containing tablet showed differences. It is very important mention that in the first 6 h of the assay, all release profiles were different compared to the commercially available reference product. The tablets containing superdisintegrants showed faster drug delivery rates and a reduction in lag time.

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Chemometrics Applied to Nuclear Magnetic Resonance Analysis

Beavis

Rusilowicz

Donarski

et al. 2019

Encyclopedia of Analytical Chemistry

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Nuclear magnetic resonance (NMR) spectroscopy provides information about the physical and chemical properties of atoms within a sample and has become an essential tool in metabolomics. Although less sensitive than mass spectrometry, NMR spectroscopy is highly reproducible and gives wider coverage in comparison to other techniques used for the analysis of complex mixtures. Recent advances in technology, advances in methodology, and increased computer power have increased the need to develop mathematical and statistical methods to analyze and interpret the complex datasets acquired. This has resulted in developments in the field of chemical informatics known as chemometrics . In contrast to targeted analyses, chemometric approaches do not initially attempt to identify particular metabolites. Instead, statistical techniques and pattern recognition methods are used to identify spectral features that show consistent trends or provide discrimination between classes. These features can provide a fingerprint for a metabolic state to be used, for example, for disease diagnostics, and individual features of interest can then be related to specific compounds and metabolic pathways using database searches. NMR‐based chemometric methods are now used in a wide range of applications including clinical diagnostics, food science and traceability, process control, monitoring genetic modification, and predicting the side effects of pharmaceuticals and their environmental effects.

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A comparative study of disintegration actions of various disintegrants using Kohonen's self-organizing maps

Cited by 32 publications

References 20 publications

A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

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Chemometrics Applied to Nuclear Magnetic Resonance Analysis

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