A Comparative Study of Efficacy of Esmolol and Fentanyl for Attenuation of Intubation Response During Laryngoscopy

Abstract

AIM:To compare the attenuation of haemodynamic changes to laryngoscopy and intubation with IV bolus Esmolol 2mg/kg and IV Fentanyl 2µg/kg. METHODS: 90 adult patients of both sex between age 18 and 55 years with ASA grade I and II normotensive with normal rhythm in ECG are divided randomly into three groups. Group-C was control group. In these patients no drug was given. Group-E was Esmolol group. In this group patients were given Inj. Esmolol-2mg/kg IV 3 min. before intubation over 30 seconds Group-F was Fentanyl group. In this group patients were given Inj. Fentanyl-2µg/kg IV 3 min. before intubation over 30 seconds. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded as baseline and after administration of study drug. RESULTS: Heart rate, systolic, diastolic blood pressures and mean arterial blood pressures were compared at pre op, 1 minute after induction and 1, 3, 5 and 10 minute intervals from the onset of laryngoscopy and intubation. Esmolol showed better attenuation of sympathetic response which is statistically highly significant. It remains significant till the end of 5 minutes. CONCLUSION: Esmolol is more effective than Fentanyl in attenuation of sympathetic response to laryngoscopy and intubation. IV. bolus dose of Esmolol 2mg/kg administered 3 minutes before laryngoscopy and intubation can be recommended to attenuate the sympathetic response to laryngoscopy and intubation without any side effects of the drug.

A Comparative Evaluation of Nitroglycerine and Esmolol in Attenuating the Haemodynamic Response to Laryngoscopy and Intubation

“…These transitory changes are maximum at 1 minute following intubation and lasts for 5-10 minutes. [1] These changes are more significant and pose serious challenges in patients with cardiovascular diseases like hypertension, coronary artery disease, aneurysmal vascular disease. [2] There is urgent need for drug which can attenuate the cardiovascular response to the laryngoscopy and intubation.…”