A comparative study of electrochemical techniques in investigating the adsorption behaviour of fibrinogen on platinum

Farcas, Mónica; Cosman, Nicholas P.; Ting, David K.; Roscoe, Sharon G.; Omanovic, Sasha

doi:10.1016/j.jelechem.2010.04.004

Cited by 32 publications

(13 citation statements)

References 80 publications

(131 reference statements)

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“…We have therefore conducted some experiments with different concentrations of Ringer solution (1/4, 1/6, and 1/12-strength) and found no dependence of the voltage excursions on concentration. Adding proteins to the solution may also deteriorate the electrochemical properties of stimulation electrodes (Cyster et al, 2003 ; Farcas et al, 2011 ; Kane et al, 2011 ), but in the case of platinum it has a protective effect against dissolution as well (Roblee et al, 1980 ; Hibbert et al, 2001 ). The first part seems to also hold for TiN electrodes, as the impedance magnitudes and voltage transients were higher directly after implantation than before, despite the similar conductivity of the tissue and Ringer solution in the acute inflammation phase.…”

Section: Discussionmentioning

confidence: 99%

Electrochemical properties of titanium nitride nerve stimulation electrodes: an in vitro and in vivo study

et al. 2015

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The in vivo electrochemical behavior of titanium nitride (TiN) nerve stimulation electrodes was compared to their in vitro behavior for a period of 90 days. Ten electrodes were implanted in two Göttingen minipigs. Four of these were used for electrical stimulation and electrochemical measurements. Five electrodes were kept in Ringer's solution at 37.5°C, of which four were used for electrical stimulation and electrochemical measurements. The voltage transients measured in vivo were 13 times greater than in vitro at implantation and they continued to increase with time. The electrochemical properties in vivo and the tissue resistance (Rtissue) followed a similar trend with time. There was no consistent significant difference between the electrochemical properties of the in vivo and in vitro electrodes after the implanted period. The differences between the in vivo and in vitro electrodes during the implanted period show that the evaluation of electrochemical performance of implantable stimulation electrodes cannot be substituted with in vitro measurements. After the implanted period, however, the performance of the in vivo and in vitro electrodes in saline was similar. In addition, the changes observed over time during the post-implantation period regarding the electrochemical properties of the in vivo electrodes and Rtissue were similar, which indicates that these changes are due to the foreign body response to implantation.

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Section: Discussionmentioning

confidence: 99%

Electrochemical properties of titanium nitride nerve stimulation electrodes: an in vitro and in vivo study

et al. 2015

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“…In the electrical circuit, constant-phase elements (CPE) were used instead of the pure capacitance to take into account the inhomogeneity present at the reinforcement/pore solution interface [36]. The impedance of a CPE is defined as Z CPE = [CPE(jω) n ] −1 [37]. During the fitting process, values of n were smaller than 1 for both samples, indicating that the behaviour of the system is not purely capacitive and that CPE should be used.…”

Section: Micro-x-ray Diffraction (μ-Xrd) and Micro-x-ray Fluorescencementioning

confidence: 99%

“…Values of resistance are expressed over a whole surface of exposed steel (steel testing area of 45.5 cm 2 ). The constant-phase element values, obtained by fitting the spectra to proposed EC, were used to calculate the capacitance values, using the equation developed by Farcas et al [37]. The resistance of the mortar and electrolyte R mortar , is similar for both steels, with values being slightly higher in the case of 10 wt.% Cr steel at the beginning of the exposure, but declining over time for both specimens.…”

Section: Micro-x-ray Diffraction (μ-Xrd) and Micro-x-ray Fluorescencementioning

confidence: 99%

Spatial distribution of crystalline corrosion products formed during corrosion of stainless steel in concrete

Serdar

Meral

Kunz

et al. 2015

Cement and Concrete Research

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The mineralogy and spatial distribution of nano-crystalline corrosion products that form in the steel/concrete interface were characterized using synchrotron X-ray micro-diffraction (μ-XRD). Two types of low-nickel highchromium reinforcing steels embedded into mortar and exposed to NaCl solution were investigated. Corrosion in the samples was confirmed by electrochemical impedance spectroscopy (EIS). μ-XRD revealed that goethite (α-FeOOH) and akaganeite (β-FeOOH) are the main iron oxide-hydroxides formed during the chlorideinduced corrosion of stainless steel in concrete. Goethite is formed closer to the surface of the steel due to the presence of chromium in the steel, while akaganeite is formed further away from the surface due to the presence of chloride ions. Detailed microstructural analysis is shown and discussed on one sample of each type of steel.

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“…While all these studies have demonstrated the promise of redox potentiometry with metallic electrodes, a greater understanding of such measurements and their adaptability to complex biological samples need to be made. Planar platinum electrodes, which are commonly used in redox potentiometry, may not be the optimum electrode to make these measurements due to the propensity for their surfaces to be biofouled [ 45 , 46 ]. Rather, a better choice for redox potentiometry studies in complex biological samples would be an appropriately nanostructured, high surface area electrode known to reduce the effects of biofouling on the electrochemical response as well as improve electron transfer rates of small molecules.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Biosensing of Ascorbic Acid, Uric Acid, and Cysteine in Microliter Volumes Using Miniaturized Nanoporous Gold Electrodes

et al. 2020

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Potentiometric redox sensing is a relatively inexpensive and passive approach to evaluate the overall redox state of complex biological and environmental solutions. The ability to make such measurements in ultra-small volumes using high surface area, nanoporous electrodes is of particular importance as such electrodes can improve the rates of electron transfer and reduce the effects of biofouling on the electrochemical signal. This work focuses on the fabrication of miniaturized nanoporous gold (NPG) electrodes with a high surface area and a small footprint for the potentiometric redox sensing of three biologically relevant redox molecules (ascorbic acid, uric acid, and cysteine) in microliter volumes. The NPG electrodes were inexpensively made by attaching a nanoporous gold leaf prepared by dealloying 12K gold in nitric acid to a modified glass capillary (1.5 mm id) and establishing an electrode connection with copper tape. The surface area of the electrodes was ~1.5 cm2, providing a roughness factor of ~16 relative to the geometric area of 0.09 cm2. Scanning electron microscopy confirmed the nanoporous framework. A linear dependence between the open-circuit potential (OCP) and the logarithm of concentration (e.g., Nernstian-like behavior) was obtained for all three redox molecules in 100 μL buffered solutions. As a first step towards understanding a real system, the response associated with changing the concentration of one redox species in the presence of the other two was examined. These results show that at NPG, the redox potential of a solution containing biologically relevant concentrations of ascorbic acid, uric acid, and cysteine is strongly influenced by ascorbic acid. Such information is important for the measurement of redox potentials in complex biological solutions.

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A comparative study of electrochemical techniques in investigating the adsorption behaviour of fibrinogen on platinum

Cited by 32 publications

References 80 publications

Electrochemical properties of titanium nitride nerve stimulation electrodes: an in vitro and in vivo study

Electrochemical properties of titanium nitride nerve stimulation electrodes: an in vitro and in vivo study

Spatial distribution of crystalline corrosion products formed during corrosion of stainless steel in concrete

Potentiometric Biosensing of Ascorbic Acid, Uric Acid, and Cysteine in Microliter Volumes Using Miniaturized Nanoporous Gold Electrodes

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