2019
DOI: 10.15616/bsl.2019.25.1.7
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A Comparative Study of [F-18] Florbetaben (FBB) PET Imaging, Pathology, and Cognition between Normal and Alzheimer Transgenic Mice

Abstract: Alzheimer's disease (AD) is highly prevalent in dementia, with no specifically effective treatment having yet been discovered. Amyloid plaques are one of the key hallmarks of AD. Transgenic mouse models exhibiting Alzheimer's disease-like pathology have been widely used to study the pathophysiology of Alzheimer's disease. In this study, we showed an age-dependent correlation between cognitive function, pathological findings, and [F-18] Florbetaben (FBB) PET images. Nineteen transgenic mice (12 with AD, 7 with … Show more

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“… 3 4 Among biomarkers reflecting cerebral amyloidosis, 18F-florbetaben (FBB) amyloid positron emission tomography (PET) has been a widely used tool. 5 6 …”
Section: Introductionmentioning
confidence: 99%
“… 3 4 Among biomarkers reflecting cerebral amyloidosis, 18F-florbetaben (FBB) amyloid positron emission tomography (PET) has been a widely used tool. 5 6 …”
Section: Introductionmentioning
confidence: 99%