A Comparative Study of High-Fat Diet Containing Fish Oil or Lard on Blood Glucose in Genetically Diabetic (db/db) Mice.

Miura, Toshihiro; Ohnishi, Yasuhiro; Takagi, Sayuki; Sawamura, Makoto; Yasuda, Noriko; Ishida, Hideyuki; Tanigawa, Keiichiro; Yamori, Yukio; Seino, Yutaka

doi:10.3177/jnsv.43.225

Cited by 15 publications

(11 citation statements)

References 26 publications

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“…The results of the plasma and liver lipid and plasma glucose in this study agree with many other reports re lated to the inhibitory effect of fish oils on the absorp tion and metabolism of nutrients; for example, the in hibitory effect on cholesterol absorption in rats (24) and the hypoglycemic effect on genetically diabetic (db/db) mice (25). The higher levels of the soluble sac charides and proteins in the cecal contents observed in mice fed MO with lower levels of plasma glucose is very interesting.…”

Section: Discussionsupporting

confidence: 92%

Cecal Environment and TBARS Level in Mice Fed Corn Oil, Beef Tallow and Menhaden Fish Oil.

Kuda

Enomoto

Yano

et al. 2000

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryTo examine the dietary effects of three lipids from different sources on intes tinal conditions, diets containing 10% corn oil (CO), 1% corn oil+9% beef tallow (BT) or 1% corn oil+9% menhaden fish oil (MO) were administered to male mice for 4 wk. Levels of total cholesterol (TC), non-esterifide fatty acids (NEFA) and glucose in plasma were lower in mice fed on MO than in mice fed on CO or BT. The plasma phospholipid (PL) level was lower for mice fed MO than in mice fed BT. Levels of the thiobarbituric acid-reactive substances (TBARS), soluble saccharides and soluble proteins in the cecum were significantly higher in mice fed on MO than in mice fed on CO or BT. The number of fecal bacteroidaceae was lower in mice fed on MO than in mice fed on BT. On the other hand, the number of fecal bifidobac teria was greater in mice fed on MO than in mice fed on CO. These results suggest the possi bility that menhaden oil affects lower intestinal microfiora through the increase of not only oxide products but also saccharides and proteins in the intestine.

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Section: Discussionsupporting

confidence: 92%

Cecal Environment and TBARS Level in Mice Fed Corn Oil, Beef Tallow and Menhaden Fish Oil.

Kuda

Enomoto

Yano

et al. 2000

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…This may result from an increase in insulin secretion and a greater sensitivity to insulin [20,[40][41][42]. We observed that the J diet lowered the plasma Glu con-centration relative to the W diet.…”

Section: Discussionmentioning

confidence: 53%

Effects of Western, Vegetarian, and Japanese Dietary Fat Model Diets with or without Green Tea Extract on the Plasma Lipids and Glucose, and Liver Lipids in Mice

Shirai¹,

Suzuki²

2004

Ann Nutr Metab

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Background/Aims: The purpose of this study was to investigate the long-term effects of three model diets containing different fats, with or without a small amount of green tea extract (GTE), on plasma lipids and glucose, and liver lipids in mice. Methods: Male mice (2 months old) fed 10% fat diets with Western (W), Vegetarian (V), and Japanese (J) fat compositions with or without 0.03% GTE for 7 months. Results: The concentrations of plasma and liver total cholesterol in animals fed the W diet were not significantly different from those fed the J diet. Plasma triacylglycerol (TG) concentrations were significantly different from one another in the following order: V > J > W diet groups. GTE supplementation significantly reduced plasma and liver TG content only in V diet group. Plasma glucose (Glu) concentrations were in the following order: W > V > J diet groups, and the GTE supplementation reduced the concentration of Glu in each diet group. The ratios of plasma n–6 to n–3 fatty acids were in the following order: V > W > J diet groups, regardless of GTE supplementation. Conclusion: These findings show the possibility that Japanese eating habits combined with drinking green tea might be a factor in preventing the onset of non-insulin-dependent diabetes mellitus.

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“…Reports from a number of studies have indicated that an intake of fish oil or 22:6n-3 suppresses plasma Glu content (Shirai and Suzuki, 2004;Kuda et al, 2000;Miura et al, 1997). In our previous study, a significant reduction in plasma Glu content was also seen following an intake of diets containing 3% or more of kazunoko lipids .…”

Section: Discussionmentioning

confidence: 75%

“…A dietary intake of fish oil or 22:6n-3 has been shown to influence plasma insulin and adipocytokine levels (Flachs et al, 2006;Peyron-Caso et al, 2002;Perez-Matute et al, 2005;Neschen et al, 2006;Miura et al, 1997;Steerenberg et al, 2002). In the present study, an intake of fish oil also significantly increased insulin, leptin, and adiponectin levels but not resistin when compared with the lard diet.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Lipids Extracted from Herring Roe Products and Fish Oil on Plasma Glucose and Adipocytokine Levels in ICR Aged Mice

Shirai

Higuchi

Suzuki

2008

FSTR

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Male mice (11 months old) were fed 5% lard, fish oil, or kazunoko (salted fish roe product) lipids for 4 months to investigate the effects of diet on plasma glucose and adipocytokines. Plasma glucose levels were significantly lower in the fish oil group than in the lard group and there was a non-significant tendency towards lower levels in the kazunoko lipid group. Plasma leptin and adiponectin levels were also significantly higher in fish oil group than in lard group and resistin levels were significantly lower in the kazunoko lipid group than the lard group, but not the fish oil group. The results suggest that kazunoko lipids might be effective as a dietary component in the prevention of coronary heart disease and diabetes even though the metabolic effects of kazunoko lipids were different from those of fish oil.

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A Comparative Study of High-Fat Diet Containing Fish Oil or Lard on Blood Glucose in Genetically Diabetic (db/db) Mice.

Cited by 15 publications

References 26 publications

Cecal Environment and TBARS Level in Mice Fed Corn Oil, Beef Tallow and Menhaden Fish Oil.

Cecal Environment and TBARS Level in Mice Fed Corn Oil, Beef Tallow and Menhaden Fish Oil.

Effects of Western, Vegetarian, and Japanese Dietary Fat Model Diets with or without Green Tea Extract on the Plasma Lipids and Glucose, and Liver Lipids in Mice

A Comparative Study of Lipids Extracted from Herring Roe Products and Fish Oil on Plasma Glucose and Adipocytokine Levels in ICR Aged Mice

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