The underwater blast response of free standing sandwich plates with a square honeycomb core and a corrugated core has been measured. The total momentum imparted to the sandwich plate and the degree of core compaction are measured as a function of (i) core strength, (ii) mass of the front face sheet (that is, the wet face) and (iii) time constant of the blast pulse. Finite element calculations are performed in order to analyse the phases of fluid-structure interaction. The choice of core topology has a strong influence upon the dynamic compressive strength and upon the degree of core compression, but has only a minor effect upon the total momentum imparted to the sandwich. For both topologies, a reduction in the mass of the front (wet) face reduces the imparted momentum, but at the expense of increased core compression.Conversely, an increase in the time constant of the blast pulse results in lower core compression, but the performance advantage over a monolithic plate in terms of imparted momentum is reduced. The sandwich panel results are compared with analytical results for monolithic plates of mass equal to that of (i) the sandwich panel and (ii) the front face alone. (Case (i) represents a rigid core while (ii) represents a core of negligible strength.) For most conditions considered, the sandwich results lie between these limits reflecting the coupled nature of core deformation and fluidstructure interaction.