A comparative study of labetalol and fentanyl on the sympathomimetic response to laryngoscopy and intubation in vascular surgeries

Babita, .; Singh, Bhupendra; Saiyed, Anjum; Meena, Reema; Verma, Indu; Vyas, Chand Kishan

doi:10.4103/2394-6954.163081

Cited by 10 publications

(10 citation statements)

References 2 publications

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“…Moreover this drug targets 5-10 times more specific beta blockade 11,23 and prevent rebound hypertension and tachycardia. 20,10 Researchers used Labetalol and nitroprusside to induce hypotension in major surgeries and showed that nitroprusside significantly increased the heart rate but cardiac output remain unchanged with labetalol administration. 11 The arterial hypertension is due to increase in cardiac output rather than increase in systemic vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of effect of Labetalol and fentanyl with only fentanyl for attenuating pressure responses to intubation and skull pin insertion in neurosurgery

2020

IJCA

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Section: Discussionmentioning

confidence: 99%

“…10 It lowers the blood pressure by decreasing systemic vascular resistance (alpha-1 blockade) whereas reflex tachycardia triggered by vasodilation is attenuated by simultaneous betablockade and cardiac output remains unchanged. 11 It has better safety profile and haemodynamic stability.…”

Section: Introductionmentioning

confidence: 99%

Comparison of effect of Labetalol and fentanyl with only fentanyl for attenuating pressure responses to intubation and skull pin insertion in neurosurgery

2020

IJCA

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“…4 It is an antihypertensive drug available in oral and parenteral form.Labetalol shows selective antagonist activity over alpha-1 adrenergic receptors and nonselective blockade over beta-1 and beta-2 adrenergic receptors. 5 It shows antagonist activity over alpha and beta receptors in the ratio of alpha: beta = 1:7 for intravenous administration. 6 Thus the present study is undertaken to evaluate the efficacy between 0.15mg/kg and 0.25mg/kg of iv Labetalol in the suppression of haemodynamic response to extubation.…”

Section: Introductionmentioning

confidence: 99%

To evaluate the efficacy between 0.15mg/Kg and 0.25mg/Kg of iv labetalol in the suppression of haemodynamic response to extubation

Sindhu¹,

Srinivas²

2020

IJCA

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Background: Tracheal extubation process evokes stress response which causes autonomic variations such as tachycardia, rise in systolic arterial blood pressure and diastolic arterial blood pressure which is potentially lethal in high risk patients. Thus this study is conducted to compare the efficacy between 0.15mg/kg and 0.25mg/kg of iv Labetalol in the suppression of haemodynamic response to Extubation. Materials and Methods: 60 participants aged between 18-55 yrs belonging to ASA 1 or 2 were randomly allocated into 2 groups. Group Lb received injection Labetalol 0.15mg/kg and Group Lt received injection Labetalol 0.25mg/kg. Heart rate, systolic arterial blood pressure and diastolic arterial blood pressure were recorded at basal, two, five, eight minutes after drug infusion, at extubation and one, three, five, eight, ten and fifteen minutes post extubation. Results: Group Lt showed a better lowering values in heart rate, systolic arterial blood pressure and diastolic arterial blood pressure after drug infusion, at Extubation, and fifteen minutes post Extubation compared to Group Lb. Conclusion: Injection Labetalol 0.25mg/kg showed a effective suppression of haemodynamic response to Extubation compared to injection Labetalol 0.15mg/kg.

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“…It lowers BP by decreasing systemic vascular resistance (a1-blockade), whereas reflex tachycardia triggered by vasodilatation is attenuated by simultaneous b-blockade. Cardiac output remains unchanged [11][12][13][14][15][16][17][18][19]. The aim of the present study was to compare the efficacy of two different doses of labetalol for controlling these hemodynamic responses to laryngoscopy and tracheal intubation under the same anesthetic techniques in hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with two different doses of labetalol in hypertensive patients

Kumar

Gandhi

Mallick

et al. 2016

Egyptian Journal of Anaesthesia

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The present study compared the efficacy of two different doses of labetalol, for attenuation of hemodynamic response to laryngoscopy and intubation in hypertensive patients. Patients and methods: 75 hypertensive patients, aged 18-60 years undergoing elective surgical procedures, require general anesthesia and orotracheal intubation. Patients were allocated to any of the three groups (25 each), Group C (control) 5 ml 0.9% saline. Group L1 (labetalol) 0.15 mg/kg diluted with 0.9% saline to 5 ml. Group L2 (labetalol) 0.3 mg/kg diluted with 0.9% saline to 5 ml. In the control group 5 ml of 0.9% saline was given i.v. 5 min prior to intubation. In the L1 group 0.15 mg/kg of labetalol was given i.v. 5 min prior to intubation. In the L2 group 0.3 mg/ kg of labetalol was given i.v. 5 min prior to intubation. All the patients were subjected to the same standard anesthetic technique. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded prior to induction, at time of intubation and 1, 3, 5, and 10 min after intubation. Mean arterial pressure (MAP) and rate pressure product (RPP) were calculated. Results: Compared to placebo both the doses of labetalol (0.15 mg/kg) and (0.3 mg/kg) significantly attenuated the rise in heart rate, systolic blood pressure, and RPP during laryngoscopy and intubation. However, the difference was not statistically significant between both doses of labetalol at intubation, 1 min, 3 min and 10 min post-intubation. Conclusion: Both doses of labetalol (0.15 mg/kg and 0.3 mg/kg) attenuate hemodynamic response to laryngoscopy and intubation in dose dependent manner.

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A comparative study of labetalol and fentanyl on the sympathomimetic response to laryngoscopy and intubation in vascular surgeries

Cited by 10 publications

References 2 publications

Comparison of effect of Labetalol and fentanyl with only fentanyl for attenuating pressure responses to intubation and skull pin insertion in neurosurgery

Comparison of effect of Labetalol and fentanyl with only fentanyl for attenuating pressure responses to intubation and skull pin insertion in neurosurgery

To evaluate the efficacy between 0.15mg/Kg and 0.25mg/Kg of iv labetalol in the suppression of haemodynamic response to extubation

Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with two different doses of labetalol in hypertensive patients

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