A Comparative Study of Lactic Acid 10% and Ammonium Lactate 12% Lotion in the Treatment of Foot Xerosis

Abstract

Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis. Clinical assessment of xerosis was performed at baseline visit, and the designated sites were evaluated at 2 and 4 weeks after treatment began. Of the 53 patients enrolled, 18 were excluded from analysis. Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment, no statistically significant difference was observed. Of the 44% of patients who did express a preference, 72% preferred Lactinol, which may account for the 20% increase in its overall use in the study.

The influence of a humectant‐rich mixture on normalz skin barrier function and on once‐ and twice‐daily treatment of foot xerosis. A prospective, randomized, evaluator–blind, bilateral and untreated‐control study

“…No irritation linked to barrier damage was found, but instead only transient sensory skin reactions, such as smarting and stinging were noted. These adverse reactions are commonly encountered when sensitive skin is exposed to products with low pH and certain ingredients, such as lactic acid , urea and menthol.…”

Current treatment options in psoriasis: topical agents

“…In addition, a betamethasone combination with a-hydroxy acids may increase safety and enhance patient tolerance owing to significant reduction in treatment duration [73]. Adverse reactions to a-hydroxy acids include mild irritation and burning [74,75]. Ammonium lactate lotion can enhance topical steroid therapy by removing hyperkeratotic scale [76].…”

Risk factors for foot ulceration in adults with end‐stage renal disease on dialysis: study protocol for a prospective observational cohort study

“…• Severity of xerosis will be graded in accordance with the Xerosis Severity Scale (mild = 1-2, moderate = 3-4, severe = 5-6) [66,67] • Skin pathology will be recorded as 'present' or 'absent'…”

“…Skin and nail pathologies have been found to be predictive of foot ulceration in people with diabetes in prospective studies [27,55]. The grading of xerosis severity will be evaluated using the Xerosis Severity Scale, which has been used in several randomised trials [66][67][68]. Skin pathology will be recorded if any of the following are present:…”