A Comparative Study of Lipid Profile and Leptin Resistance in Children With Metabolic Syndrome Depending on Hypertension in Kyiv

Abstract

The aim: To compare lipid metabolism and leptin levels among the children with and without hypertension to identify associated risk factors for the course of metabolic syndrome in children. Materials and methods: This observational, cross-sectional study recruited children from the Rheumocardiology Department of Children’s Clinical Hospital No 6 in Kyiv, with metabolic syndrome, identification of waist-to-height ratio, leptin level, homeostasis model assessment of insulin resistance and lipid profile. The main group included 41 children with metabolic syndrome and hypertension and the control group included 40 children with metabolic syndrome without hypertension. Statistical data analysis was performed using the MedStat 2.6.2. package. Results: A total of 81 children aged 10 to 17 with metabolic syndrome were examined. The group of children with hypertension had significantly lower high-density lipoprotein cholesterol (0.85±0.04) than children without hypertension (0.94±0.03), with p < 0.05. Leptin resistance was detected in 65.2% of children with hypertension and 35.3% of children with normal blood pressure (p < 0.01). Conclusions: Children with metabolic syndrome and hypertension had a significantly higher body mass index and waist circumference as opposed to children with normal blood pressure. In the lipid profile high-density lipoprotein cholesterol was significantly lower in hypertensive children. There was no reliable difference in other lipid profile indicators between the two groups, but there was an upward trend of them in group with hypertension. Leptin resistance is also significantly higher in hypertensive children.

Сlinical Characteristics of Children and Adolescents With Metabolic Syndrome in Kyiv

“…Ñë³ä çàçíà÷èòè, ùî IDF -öå ºäèíå âèçíà÷åííÿ, â ÿêîìó àáäîì³íàëüíå îaeèð³ííÿ º îáîâ'ÿçêîâèì êðèòåð³ºì. Íàäàííÿ ïåðâèííîñò³ â ä³àãíîñòèö³ âèì³ðþâàííþ îêðóaeíîñò³ òà볿 º íàóêîâî îá-´ðóíòîâàíèì ÷èñëåííèìè äîñë³äaeåííÿìè [9,10,11]. Òàê, çã³äíî ç ìåòà-àíàë³çîì 2018 ðîêó, ä³òè ç³ ñï³ââ³äíîøåííÿì îêðóaeíîñò³ òà볿 äî çðîñòó (WtHR) ≥0,5 ìàþòü â÷åòâåðî âèùèé ðèçèê êëàñòåðíèõ êðèòåð³¿â ÌÑ ³ ùî öåé ðèçèê âèïðàâäîâóº ïî÷àòîê ïðîô³ëàêòè÷íèõ çàõîä³â [12].…”

“…It should be noted that the IDF is the only definition in which abdominal obesity is a mandatory criterion. The primary diagnostic role of waist circumference measurement is scientifically supported by numerous studies [9,10,11]. For example, according to a 2018 meta-analysis, children with a waist-to-height ratio (WHtR) ≥ 0.5 have a fourfold higher risk of meeting cluster criteria for MetS, and this risk justifies the initiation of preventive measures [12].…”