A Comparative Study of Liquid Nitrogen  Cryotherapy as Monotherapy versus  in Combination with Podophyllin in the  Treatment of Condyloma Acuminata

Sharma, Nidhi; Sharma, Sanjeev; Singhal, Chetna

doi:10.7860/jcdr/2017/23797.9339

Cited by 17 publications

(14 citation statements)

References 11 publications

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“…Despite the availability of many destructive and immunotherapeutic modalities for the treatment of warts, the incidence of resistant and recurrent warts is steadily rising, particularly with the use of monotherapies. Therefore, many combination therapies have been intensively studied in order to increase the response rate, decrease the adverse effects, and minimize the recurrence potential …”

Section: Introductionmentioning

confidence: 99%

Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts

Marei

Nofal

Alakad

et al. 2019

J of Cosmetic Dermatology

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Background The burden of human papillomavirus (HPV) infection and HPV‐associated diseases is consistently growing worldwide. Several combination therapies are being tested nowadays for the treatment of recalcitrant warts, with promising results. Aims To evaluate the potential therapeutic role of combined bivalent HPV vaccine (Cervarix) and Candida antigen versus candida antigen alone in the treatment of multiple recalcitrant warts. Patients/Methods Forty patients with recalcitrant warts were enrolled into this study. They were divided into two groups (A and B), each including 20 patients. Patients in the group (A) received intralesional Candida antigen injection alone for five sessions at 2‐week intervals. Patients in the group B received combined treatment of bivalent recombinant HPV vaccine and intralesional Candida antigen. Candida antigen was administered as in the group A, while Cervarix vaccine was given intramuscularly at 0, 1, and 6 months as scheduled. Follow‐up was made monthly for 6 months to detect any possible recurrence. Results Eight patients (40%) in the group (A) showed complete clearance of warts after intralesional Candida antigen injection alone, while 14 patients (70%) in the group (B) showed complete regression of warts after the combined therapy. No significant side effects were reported in both groups, and no recurrence was detected. Conclusion Bivalent human papillomavirus vaccine combined with Candida antigen is a promising, effective, and safe modality for the treatment of multiple recalcitrant warts.

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Section: Introductionmentioning

confidence: 99%

Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts

Marei

Nofal

Alakad

et al. 2019

J of Cosmetic Dermatology

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“…This treatment uses liquid nitrogen to freeze and destroy the lesional tissue causing necrosis (Alam and Stiller, 2001). Compared with surgical excision, cryotherapy has been reported to have a recurrence rate of 20e40% (Chang and Welton, 2004;Sharma et al, 2017). However, the lower efficacy can be offset by the reduced risk, pain, and recovery time associated with cryotherapy.…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

SnapshotDx Quiz: October 2020

Barber

Chong

2020

Journal of Investigative Dermatology

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“…Podophyllin is a resin extracted from the root of the P. peltatum (28). When treating genital warts, a recent study showed that a combination of cryotherapy and podophyllin therapy is more efficient than cryotherapy alone, shortening the treatment regimen (29). According to a meta-analysis of 9 randomised controlled trials, podophyllotoxin, the main ingredient of podophyllin, in the concentration of 0.5 % caused complete clearance of genital warts in 56.41 % of patients.…”

Section: Condyloma Accuminatamentioning

confidence: 99%

Application of medicinal plants in several dermatovenerological entities

et al. 2019

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Treatment of skin conditions with medicinal plants has been an ongoing human activity lasting over thousands of years. The use of specific plant species developed regionally, based on local flora. Commonly used medicinal plants for dermatological complaints are: Phlebodium aureum (L.) J. Sm., Ginkgo biloba L., Rosmarinus officinalis L., Panax ginseng C.A.Mey., Allium cepa L., Aloe vera (L.) Burm.f., Capsicum annuum L., Berbe ris aquifolium Pursh, Camellia sinensis (L.) Kuntze, and Podophyllum peltatum L. The demand for complementary therapeutics is an emerging trend due to the awareness of potential side effects that synthetic drugs might cause. More scientific evidence and better documentation are needed before advising dermatologic patients on herbal medicinal treatment. Standardised extracts and formulations with proven clinical efficacy should be developed for this cause. Here provided review entails the use of herbal medicinal products in the treatment of frequent chronic skin diseases, such as vitiligo, alopecia, psoriasis and genital warts.

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A Comparative Study of Liquid Nitrogen Cryotherapy as Monotherapy versus in Combination with Podophyllin in the Treatment of Condyloma Acuminata

Cited by 17 publications

References 11 publications

Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts

Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts

SnapshotDx Quiz: October 2020

Application of medicinal plants in several dermatovenerological entities

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