AIM: The study was intended to evaluate the effectiveness of piezosurgery in enucleation of radicular odontogenic cysts in comparison to the conventional technique from both the clinical and radiographic perspectives. Methods: Fourteen (8 females and 6 males) patients with age range of 30-55 years who had radicular cysts associated with non-vital teeth, were operated at the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University. The patients were randomly divided into 2 groups;1) the study group (7 patients) in which cyst enucleation using piezosurgery was employed, 2) control group in which the cysts were removed using the conventional technique. The following parameters were assessed; postoperative pain, time of operation, hemorrhage control and field visibility, ease of operation, neurosensory evaluation and radiographic percentage of change in bone defect volume between preoperative and 3-months postoperative values. Results: 9 maxillary and 5 mandibular radicular cysts were enucleated in both groups. The piezosurgery group showed a statistically significant control over heamorrhage and a clearer, more visible field when compared to the conventional group. The difference between the times required for cyst enucleation in both groups was statistically significant, with longer time recorded in the piezosurgery group. No complications were observed during execution of piezosurgery techniques. On the other hand, with the conventional technique, 2 patients complained of neurosensory involvement which was resolved over time. Also, the piezosurgery group showed a significantly more reduction of bone defect volume than the conventional surgery group, 3 months after the operation in comparison to the preoperative baseline value. Conclusions: Piezosurgery proved to be more effective for cyst enucleation than the conventional method. Moreover, the piezosurgery was a more efficient choice for preservation of the important anatomical structures while providing a clearer field of surgery. Also, better early healing potential of the bone defect resulting from cyst enucleation was detected with piezosurgery.