A comparative study of mast cells in appendix

Nagaraj, G.; Das, Subhashish; Venkatesha, Mahesh; Ml, Harendra Kumar

doi:10.5455/ijmsph.2015.02032015330

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mean mast cell count was highest in chronic appendicitis followed by acute appendicitis, and histology negative acute appendicitis (HNAA) and least in appendices removed in the course of surgeries done for some other disease which correlated with the studies done by Shah AA et al 16 , Kolur A et al 6 , Singh U.R et al 17 , Coskun N et al 18 , Nagaraj G et al 19 , Kumaran C et al 20 , Yang Z et al 21 . Increase in mean mast cell count was also highest in chronic appendicitis followed by acute appendicitis in studies done by Sonti S 22 and Naik R 23 which correlated with our study.…”

Section: Results:-supporting

confidence: 65%

A Study of Mast Cells in Surgically Resected Appendix.

Verma¹,

R.M²,

R.M³

et al. 2016

IJAR

View full text Add to dashboard Cite

Section: Results:-supporting

confidence: 65%

A Study of Mast Cells in Surgically Resected Appendix.

Verma¹,

R.M²,

R.M³

et al. 2016

IJAR

View full text Add to dashboard Cite

“…Type I hypersensitivity reaction causes degranulation of mast cells, release of mediators by mast cells might be another triggering factor for the sequence of events leading to appendicitis [12]. Correlation between mast cell density, neural ganglia hypertrophy and fibrosis in cases of chronic appendicitis as seen in the present study was in concordance with studies conducted by Nagaraj G et al [4], Kolur A et al [7], Sonti S et al [8], Sharma J et al [14], Kumaran C et al [15] and Naik R et al [16], mast cells have been implicated in the pathogenesis of fibrosis and neuronal hypertrophy in chronic appendicitis due to release of growth factors leading to fibroblastic and neuronal proliferation, this was in agreement with the findings in the other studies [4,7,8,14,15,16]. In the present study highest mean eosinophil count was seen in the mucosa of acute suppurative appendicitis and lowest eosinophil count was seen in the muscularis propria of chronic appendicitis.…”

Section: Original Research Articlesupporting

confidence: 91%

“…Eosinophilic infiltration of muscularis propria has been seen in acute appendicitis and it is postulated that acute appendicitis is triggered by Type I hypersensitivity [6]. Hence mast cells and eosinophils have important role to play in the pathogenesis of appendicitis as concluded by many studies [4,5,6,7,8,9,10,11,12].…”

Section: Discussionmentioning

confidence: 99%

Study of mast cell and eosinophil count in surgically resected appendix

Priya

Giriyan

2019

Trop J Pathol Microbiol

View full text Add to dashboard Cite

Introduction:Appendix is a normal true diverticulum of the caecum that is prone to acute and chronic inflammation. Mast cells are present in chronic inflammatory reactions and they secrete cytokines that promote inflammation. Eosinophils are abundant in immune reactions mediated by IgE and in parasitic infection. Objective: To evaluate mast cell and eosinophil count variation in appendicitis and to suggest their possible role in pathogenesis of appendicitis. Materials and Methods: It is a two-year prospective study done on 470 resected specimens of appendices received for histopathology. Results: Mast cells and eosinophils were present in all the appendicular lesions studied. Mean mast cell count was highest in chronic appendicitis and lowest in acute appendicitis. Mucosa of chronic appendicitis showed highest count, lowest was seen in the muscularis propria of acute appendicitis compared to normal / unremarkable appendix taken as controls. Correlation between mast cell density, fibrosis and neural ganglia hypertrophy was seen in chronic appendicitis. Mean eosinophil count was highest in acute suppurative appendicitis and lowest in chronic appendicitis, with highest count in the mucosa of acute suppurative appendicitis and lowest in the muscularis propria of chronic appendicitis. Conclusion: The presence of mast cells and eosinophils in cases of appendicitis supports the allergic theory of appendicitis in which the Type I hypersensitivity reaction leads to recruitment of eosinophils and discharge of primary and secondary mediators of inflammation by degranulation of mast cells which play a role in pathogenesis of appendicitis.

show abstract

“…Similarly, few study findings showed eosinophilic infiltra on in muscularis propria layers of acute appendici s and postulated that acute appendici s is triggered by Type I hypersensi vity. Thus proving the important role of eosinophil in the pathogenesis of [11][12][13][16][17][18][19] appendici s.…”

mentioning

confidence: 98%

Eosinophil Count Variation among Histopathological Features of Appendectomy Specimens at Birat Medical College Teaching Hospital

Kafle¹,

Singh²,

Kafle³

et al. 2020

Birat J. Health Sci.

View full text Add to dashboard Cite

Introduction: The histopathological examination of appendectomy specimens is the gold standard method for diagnosis. The presence of eosinophil besides other inflammatory cells like neutrophils and mature lymphocytes within different histological layers of appendectomy specimens are common findings for labeling it under various groups. This finding supports the assumption that appendicitis is triggered by Type 1 hypersensitivity reaction. Objective: To evaluate the eosinophil count variation in appendectomy specimens in patients with the clinical diagnosis of appendicitis. Methodology: This is a cross sectional hospital based study of 144 appendectomy specimens obtained in Department of Pathology, Birat Medical College Teaching Hospital from January 2019 to December 2019. Socio-demographic data, association of histopathological patterns with age groups, gender and eosinophil count in various histopathological groups was compared and cross-tabulated using SPSS version 16. Result: Among 144 appendectomy specimens, male gender (50.70%) of 15-24 years age group (36.80%) was predominant. The commonest histopathological diagnosis was acute appendicitis (31.25%) with highest eosinophil count in all of its histological layers. The association of various histopathological patterns with age groups and gender were not statistically significant, whereas it revealed statistically significant correlation between eosinophil counts in all histological layers. Conclusion: Findings suggest that the eosinophil count variation in the entire histological layers correlate well among different histopathological patterns of appendectomy specimens. This reflects the high diagnostic value of evaluating the eosinophil count in appendectomy specimens.

show abstract

A comparative study of mast cells in appendix

Cited by 3 publications

References 0 publications

A Study of Mast Cells in Surgically Resected Appendix.

A Study of Mast Cells in Surgically Resected Appendix.

Study of mast cell and eosinophil count in surgically resected appendix

Eosinophil Count Variation among Histopathological Features of Appendectomy Specimens at Birat Medical College Teaching Hospital

Contact Info

Product

Resources

About