A comparative study of middle cerebral pressure in dogs and macaques

Abstract

2. The effect of occlusion of the main vessels in the neck is shown to differ considerably in the two species. Blood pressure within the forebrain of the dog is shown to be largely dependent upon the integrity of the external carotid artery, whereas in the monkey the external carotid artery is without effect in the maintenance of forebrain blood pressure. Occlusion of the four major arteries in the neck is shown to produce a greater effect in the macaque and to be accompanied by signs of medullary ischaemia in this species.3. After occlusion of the main middle cerebral artery, arterial pressure measured distal to the occlusion depends upon the integrity of collateral vessels from the other cerebral arteries. When only a branch of the middle cerebral artery is occluded, the greater part of the residual blood pressure depends upon anastomoses from other branches of the middle cerebral artery itself.

The Distribution and Density of Reduced Cerebral Blood Flow Following Acute Middle Cerebral Artery Occlusion: An Experimental Study by the Technique of Hydrogen Clearance in Baboons

“…It seems clear that the ischemic zone established by such occlusion is only slowly modified in experimental primates. This observation is in keeping with changes noted in intraarterial pressure in the pial network observed some years ago 27 in monkeys, in which no recovery of intravascular pressure could be detected up to one hour following middle cerebral occlusion. It is of note, however, that detectable recovery of such pressure was evident in the dog under similar circumstances.…”

Role of Large Arteries in Regulation of Cerebral Blood Flow in Dogs

“…Two lines of evidence, however, suggest that large arteries may serve an important resistance function in the cerebral circulation. First, there is a significant pressure gradient along large arteries that supply the brain (1)(2)(3)(4)(5)(6)(7). For example, when systemic arterial pressure is 100 mm Hg in cats, pressure in pial arteries 300 ,um in diameter is about 70 mm Hg (7).…”

Pial arterial pressure in cats following middle cerebral artery occlusion. 1. Relationship to blood flow, regulation of blood flow and electrophysiological function.

“…Heat conductance of the non-perfused cortex after cardiac arrest is 10.2; blood flow, in consequence, fell to about 30%, which is also in line with previous quantitative measurements. 8 Symon and coworkers 20,21 reported in the sixties an experimental investigation of pial artery pressure fol lowing middle cerebral artery occlusion in dogs and monkeys. This study is not directly comparable with the present one because pial artery pressure was meas ured with small catheters which occluded the vessel lumen, a methodological difference which presumably accounts for the fact that prior to ischemia pial blood pressure amounted up to 95% of femoral artery pres sure.…”