A Comparative Study of Quinine and Artemether in the Treatment of Severe Malaria in Nigerian Children

Aguwa, C. N.; Ukwe, Chinwe Victoria; Adibe, Maxwell Ogochukwu

doi:10.4314/tjpr.v9i1.52030

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…This study found that most of the patients were married female, below the age of 50 years and engaged in low to moderate levels of physical activity. Similar sociodemographic characteristics was observed in previous studies conducted in Nigeria (Enwere et al, 2006;Adibe et al, 2009;Jimoh et al, 2011;Eze et al, 2011;Dada et al, 2021). This may be related to the fact that the health seeking behaviour of most urban dwellers in the country is relatively comparable and more female visit the public hospital compared to the male counterparts (Adams & Carter, 2011).…”

Section: Medication Prescriptionsupporting

confidence: 88%

Cardiovascular Risk Factors and Prescription Pattern Among Patients With Type 2 Diabetes Mellitus in North-East Nigeria

DAVID

SOREMEKUN

KATAGUM

et al. 2022

BIMA

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Cardiovascular disesaes are the leading cause of morbidity and mortality among diabetic patients. This study was a 12-months retrospective cross sectional audit of case folders of adult (>18 years) type 2 diabetic patients, who attended clinic at two (2) referral hospitals in North-East Nigeria, between June 2017 and May 2018. Patients’ data including socio-demographic characteristics, cardiovascular risk factors, medication history and clinical characteristics were retrieved. The data were presented as proportions and percentages in tables and pie chart formats. The analysis was done using statistical package for social sciences (SPSS) version 21.0. Of the 807 case folders that were reviewed, 64.5% were female patients, with majority (61.3%) below 50 yearsof age and 90.2% were married. Over 50% had secondary/primary education and most (57.9%) were unskilled labourers. About one-third (34.6%) were engaged in moderate to regular physical activities. The prevalence of hypertension, dyslipidaemia and obesity was 84.8%, 5.1% and 47.1% respectively. More than three quarters of the patients (87%) were on multiple oralantidiabetic agents and metformin was the most prescribed medication (93.8%). The antihypertensive agents with the highest prescription rate was lisinopril (57.9%), while 50.9%, 6.5%, and 2.7% received low dose acetylsalicylic acid, lipid lowering agents and pregabalin respectively. Hypertension was the most prevalent cardiovascular risk factor in the study population, followed by overweight/obesity. The prescription rate of metformin and Lisinopril is commendable, but there is need to increase the use of statins and pregabalin in the study settings.

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Section: Medication Prescriptionsupporting

confidence: 88%

Cardiovascular Risk Factors and Prescription Pattern Among Patients With Type 2 Diabetes Mellitus in North-East Nigeria

DAVID

SOREMEKUN

KATAGUM

et al. 2022

BIMA

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Temperature changes in the course of treatment of severe malaria patients with artemether and quinine

Osonuga¹,

Osonuga

2011

Asian J Med Sci

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Objective: Severe malaria is a medical emergency with devastating multi-systemic effects, if not promptly treated with sensitive and safe drugs, death is imminent. Quinine and artemether are antimalarial drugs that are used in treating severe malaria. Efforts in this study were directed at comparing temperature changes in the cause of treatment of severe malaria patients with artemether and quinine in Ikenne local Government area of Ogun State, Southwest Nigeria. Material & Methods: 32 patients in the study were randomly assigned to receive either artemether or quinine under medical supervision. 16 patients were allocated into two treatment groups. Patients in the quinine treatment were given 10mg/kg body weight quinine into 5% dextrose/saline intravenously 8hourly whilst artemether group were given 1.6mg/kg body weight intramuscularly for 5days. The patients temperature were then followed up for 14days. Results: A total of 28 out of 32 patients enrolled into the study had temperature ≥ 37.5 °C at day 0. The mean fever clearance time for quinine treatment group was 46.50 ± 20.49 hours while that of artemether group was 72.0 ± 27.7 hours (p=0.006). Fever was completely resolved in both treatment group at day 14. Conclusion: Results from this study indicated that quinine relative to artemether has a faster and sustained recovery from increased in temperature. Key Words: Severe malaria; artemether; quinine; temperature DOI: 10.3126/ajms.v2i1.3351 Asian Journal of Medical Sciences 2 (2011) 41-45

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A Comparative Study of Quinine and Artemether in the Treatment of Severe Malaria in Nigerian Children

Cited by 2 publications

References 13 publications

Cardiovascular Risk Factors and Prescription Pattern Among Patients With Type 2 Diabetes Mellitus in North-East Nigeria

Cardiovascular Risk Factors and Prescription Pattern Among Patients With Type 2 Diabetes Mellitus in North-East Nigeria

Temperature changes in the course of treatment of severe malaria patients with artemether and quinine

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