This study aimed to examine the trend of ambient air pollution (i.e., ozone (O3), nitrogen monoxide (NO), nitrogen dioxide (NO2), nitrogen oxides (NOx), sulfur dioxide (SO2), carbon monoxide (CO), benzene (C6H6) and particulate matter with an aerodynamic diameter smaller than 10 microns (PM10), and non-methane hydrocarbons (NMHCs) at 10 monitoring stations located in the main residential and industrial areas in the State of Kuwait over 6 years (2012–2017). We found that the SO2 level in industrial areas (0.065 ppm) exceeded the allowable range of SO2 in residential areas (0.030 ppm). Air pollution variables were defined by the Environmental Public Authority of Kuwait (K-EPA). In this study, integrated statistical analysis was performed to compare an established air pollution database to Kuwait Ambient Air Quality Guidelines and to determine the association between pollutants and meteorological factors. All pollutants were positively correlated, with the exception of most pollutants and PM10 and O3. Meteorological factors, i.e., the ambient temperature, wind speed and humidity, were also significantly associated with the above pollutants. Spatial distribution mapping indicated that the PM10 level remained high during the southwest monsoon (the hot and dry season), while the CO level was high during the northeast monsoon (the wet season). The NO2 and O3 levels were high during the first intermonsoon season.