A comparative study of silver nanoparticle dissolution under physiological conditions

Steinmetz, Lukas; Geers, Christoph; Balog, Sandor; Bonmarin, Mathias; Rodríguez‐Lorenzo, Laura; Taladriz‐Blanco, Patricia; Rothen‐Rutishauser, Barbara; Petri‐Fink, Alke

doi:10.1039/d0na00733a

Cited by 19 publications

(9 citation statements)

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“…Silver nanoparticles (AgNPs) exhibit unique and interesting properties, including notable physiological characteristics and broad applicability [64]. In this work, AgNPs were prepared via a solution process in a very short time, and were well characterized.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports showed that the cytotoxicity of cancer cells is greatly affected and is responsible for the regulation of cancer cell growth [65,66]. Despite this, several other factors were also affected, such as the shape of the nanostructures, size, composition of cells, culture medium, doses of nanostructures, and pH [64,66]. The morphological changes after the interaction of different concentrations (2, 5, 10, 25, 50, 100 µL/mL) of AgNPs with cancer cells were observed using an inverted microscope after a 24 h incubation period, and cell death was observed.…”

Section: Discussionmentioning

confidence: 99%

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Silver Nanoparticles: An Instantaneous Solution for Anticancer Activity against Human Liver (HepG2) and Breast (MCF-7) Cancer Cells

Al‐Khedhairy

Wahab

2022

Metals

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Cancer is a cataclysmic disease that affects not only the target organ, but also the whole body. Metal-based nanoparticles (NPs) have recently emerged as a better option for the treatment of this deadly disease. Accordingly, the present work describes a means to control the growth of cancer cells by using colloidal silver nanoparticles (AgNPs) processed via homemade solutions and the characterization of these materials. The AgNPs may become an instantaneous solution for the treatment of these deadly diseases and to minimize or remove these problems. The AgNPs exhibit excellent control of the growth rate of human liver (HepG2) and breast (MCF-7) cancer cells, even at a very low concentrations. The cytotoxic effects of AgNPs on HepG2 and MCF-7 cancer cells were dose dependent (2–200 μg/mL), as evaluated using MTT and NRU assays. The production of reactive oxygen species (ROS) was increased by 136% and 142% in HepG2 and MCF-7 cells treated with AgNPs, respectively. The quantitative polymerase chain reaction (qPCR) data for both cell types (HepG2 and MCF-7) after exposure to AgNPs showed up- and downregulation of the expression of apoptotic (p53, Bax, caspase-3) and anti-apoptotic (BCl2) genes; moreover, their roles were described. This work shows that NPs were successfully prepared and controlled the growth of both types of cancer cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Silver Nanoparticles: An Instantaneous Solution for Anticancer Activity against Human Liver (HepG2) and Breast (MCF-7) Cancer Cells

Al‐Khedhairy

Wahab

2022

Metals

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“…21,30 Upon contact with physiological fluids or physical barriers, via different administration routes, NPs may undergo a process of aggregation and/or dissolution. 31,32 In addition, the different constitution of physiological fluids (e.g., proteins, lipids and electrolytes) including blood, respiratory and gastrointestinal mucus, and tear fluid might affect NP properties and thus cell-NP interactions. [33][34][35] Inhalation has been used for the administration of nanomaterials to treat lung diseases or for systemic delivery.…”

Section: Cellular Uptake Mechanisms Of Npsmentioning

confidence: 99%

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

et al. 2021

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“…However, the preparation of highly reproducible monodisperse AgNPs is much more difficult than for gold nanoparticles (AuNPs) due to the higher reactivity of Ag atoms than Au atoms [ 20 ]. In addition, it has been reported in the literature that AgNPs undergo dissolution in aqueous solutions, which limits their applicability as SERS substrates, especially for environmental samples [ 21 ]. Based on this, despite the larger scattering contribution and thus higher SERS enhancement factor of AgNPs compared to AuNPs, this study was conducted utilizing 14 nm and 46 nm spherical AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Detection of Sub-Micro- and Nanoplastic Particles on Gold Nanoparticle-Based Substrates through Surface-Enhanced Raman Scattering (SERS) Spectroscopy

et al. 2021

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Small plastic particles such as micro- (<5 mm), sub-micro- (1 µm–100 nm) and nanoplastics (<100 nm) are known to be ubiquitous within our surrounding environment. However, to date relatively few methods exist for the reliable detection of nanoplastic particles in relevant sample matrices such as foods or environmental samples. This lack of relevant data is likely a result of key limitations (e.g., resolution and/or scattering efficiency) for common analytical techniques such as Fourier transform infrared or Raman spectroscopy. This study aims to address this knowledge gap in the field through the creation of surface-enhanced Raman scattering spectroscopy substrates utilizing spherical gold nanoparticles with 14 nm and 46 nm diameters to improve the scattering signal obtained during Raman spectroscopy measurements. The substrates are then used to analyze polystyrene particles with sizes of 161 nm or 33 nm and poly(ethylene terephthalate) particles with an average size of 62 nm. Through this technique, plastic particles could be detected at concentrations as low as 10 µg/mL, and analytical enhancement factors of up to 446 were achieved.

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A comparative study of silver nanoparticle dissolution under physiological conditions

Abstract: Upon dissolution of silver nanoparticles, silver ions are released into the environment, which are known to induce adverse effects. However, since dissolution studies are predominantly performed in water and/or at...

Cited by 19 publications

References 50 publications

Silver Nanoparticles: An Instantaneous Solution for Anticancer Activity against Human Liver (HepG2) and Breast (MCF-7) Cancer Cells

Silver Nanoparticles: An Instantaneous Solution for Anticancer Activity against Human Liver (HepG2) and Breast (MCF-7) Cancer Cells

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

Detection of Sub-Micro- and Nanoplastic Particles on Gold Nanoparticle-Based Substrates through Surface-Enhanced Raman Scattering (SERS) Spectroscopy

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