A comparative study of tarsorrhaphy and amniotic membrane transplantation in the healing of persistent corneal epithelial defects

Dhillon, Hennaav Kaur; Bahadur, Harsh; Raj, Anuradha

doi:10.4103/ijo.ijo_617_19

Cited by 13 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mean area of epithelial defect was 30.74 ± 27.34 mm 2 in study by Dhillon et al, 10 which was almost similar to the mean area of PED in our study. Whereas mean area (±SD) of PED in a study by Seitz et al 9 ranged from 13.86 ± 4.37 in erosions to 10.5±3.74 mm 2 in ulcers.…”

Section: Discussionsupporting

confidence: 90%

Role of tarsorrhaphy in healing of persistent epithelial defects in today’s era

Shuja¹,

Rana²,

Dwivedi³

et al. 2020

IJOOO

View full text Add to dashboard Cite

Tarsorrhaphy has always been advised for management of persistent epithelial defects, but it is losing it's importance in present era. Materials and Methods: It was a prospective interventional study. Twenty-one patients of persistent epithelial defects presented over a period of two years at a tertiary hospital. They underwent tarsorrhaphy, along with medical management. All patients were followed up for a minimum period of two months. Observation: Eighty-five percent of patients with PED resolved with tarsorrhaphy alone. Rest three patients which failed to heal, underwent amniotic membrane transplantation at 4 th week as add-on procedure, following which they resolved. Discussion: Tarsorrhaphy helps in healing of PED by decreasing the interpalpebral fissure and retaining the tears and medicines in cul-de-sac. It also decreases the windshield wiper effect of eyelid margins. Conclusion: Tarsorrhaphy should always be considered as first modality for treating the PED.

show abstract

Section: Discussionsupporting

confidence: 90%

Role of tarsorrhaphy in healing of persistent epithelial defects in today’s era

Shuja¹,

Rana²,

Dwivedi³

et al. 2020

IJOOO

View full text Add to dashboard Cite

show abstract

“…4 Amniotic membranes contain a plethora of growth factors that facilitate wound healing, provide a scaffold for reepithelialization, and have anti-inflammatory properties 5 and have proven to be effective for the treatment of PEDs. 6,7 Commercially available amniotic membrane implantation can be performed without the need for sutures. Most reports concerning commercial amniotic membranes have reported on the cryopreserved ProKera (Bio-Tissue, Miami, FL) with encouraging results for the treatment of bacterial keratitis, 8 alkali burns, 9 partial LSCD, 10 acute toxic epidermal necrolysis, 11 as well as PEDs.…”

Section: Introductionmentioning

confidence: 99%

Sutureless dehydrated amniotic membrane for persistent epithelial defects

Trinh

Sorkin

Cohen

et al. 2021

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To report outcomes of a sutureless dehydrated amniotic membrane for persistent epithelial defects (PED). Methods: This retrospective study included consecutive patients with a PED (⩾14 days) treated with a sutureless dehydrated amniotic membrane and bandage contact lens (BCL). Included were patients with an epithelial defect that did not respond to treatment with a BCL. Excluded were patients with a follow-up time of less than 3 months. Results: Nine eyes of eight patients with a mean age of 54.6 ± 10.9 years (range 38–73 years) were included in this study. The main etiology of the PED was limbal stem cell deficiency ( n = 5/9) due to Stevens-Johnson Syndrome ( n = 2/5), glaucoma procedures ( n = 1/5), graft-versus-host disease ( n = 1/5) and severe allergic reaction ( n = 1/5). Additional etiologies included neurotrophic cornea ( n = 2/9), post keratoplasty and severe dry eye disease ( n = 2/9). Time from PED presentation to amnion treatment was 65.9 ± 60.6 days (range 15–189 days) with the area of the PED being 11.0 ± 12.2 mm2 (range 1.0–36.0 mm2). The amnion was absorbed within 2 weeks in 100% of the cases. Following insertion of the amnion, resolution of the PED was achieved in 8/9 eyes (89%) without the need for additional interventions within 17.8 ± 9.6 days (range 7–35 days). LogMAR BCVA improved from 0.94 ± 0.88 to 0.37 ± 0.25 ( p = 0.036) with no complications or recurrences recorded. Conclusions: Sutureless dehydrated amniotic membrane achieved resolution of PEDs secondary to various etiologies in 89% of eyes with a significant improvement in vision demonstrated. Further studies are needed to assess long term safety and effectiveness.

show abstract

“…Tarsorrhaphy in this study was used as a painless adjunct therapy to enhance protection of the eye. Tarsorrhaphy is commonly performed in human patients with persistent corneal epithelial defects failing to respond to medical treatments ( Dhillon et al, 2020 ). It can be temporary or permanent and partial or complete, depending on the need.…”

Section: Discussionmentioning

confidence: 99%

A Liquid Hydrogel to Restore Long Term Corneal Integrity After Perforating and Non-Perforating Trauma in Feline Eyes

Juárez

Djallali

Piché

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Purpose: To evaluate long-term in vivo functionality of corneas regenerated using a cell-free, liquid hydrogel filler (LiQD Cornea) after deep corneal trauma in the feline model.Methods: Two healthy cats underwent 4 mm diameter stepwise 250/450 µm deep surgical corneal ablation with and without needle perforation. The filler comprising 10% (w/w) collagen-like peptide conjugated to polyethylene glycol (CLP-PEG) and 1% fibrinogen and crosslinked with 2% (w/w) 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM), was applied to the wound bed previously coated with thrombin (250 U/ml). In situ gelation occurred within 5 min, and a temporary tarsorrhaphy was performed. Eyes were examined weekly for 1 month, then monthly over 12 months. Outcome parameters included slit-lamp, Scheimpflug tomography, optical coherence tomography, confocal and specular microscopy, and immunohistochemistry studies.Results: The gelled filler was seamlessly incorporated, supporting smooth corneal re-epithelialization. Progressive in-growth of keratocytes and nerves into the filler corresponding to the mild haze observed faded with time. The regenerated neo-cornea remained stably integrated throughout the 12 months, without swelling, inflammation, infection, neovascularization, or rejection. The surrounding host stroma and endothelium remained normal at all times. Tomography confirmed restoration of a smooth surface curvature.Conclusion: Biointegration of this hydrogel filler allowed stable restoration of corneal shape and transparency in the feline model, with less inflammation and no neovascularization compared to previous reports in the minipig and rabbit models. It offers a promising alternative to cyanoacrylate glue and corneal transplantation for ulcerated and traumatized corneas in human patients.

show abstract

A comparative study of tarsorrhaphy and amniotic membrane transplantation in the healing of persistent corneal epithelial defects

Cited by 13 publications

References 5 publications

Role of tarsorrhaphy in healing of persistent epithelial defects in today’s era

Role of tarsorrhaphy in healing of persistent epithelial defects in today’s era

Sutureless dehydrated amniotic membrane for persistent epithelial defects

A Liquid Hydrogel to Restore Long Term Corneal Integrity After Perforating and Non-Perforating Trauma in Feline Eyes

Contact Info

Product

Resources

About