A Comparative Study of the Distribution and Fatty Acid Composition of the Lipoproteins in the Fetal and Maternal Plasma of Sheep

Noble, R. C.; Shand, John H.

doi:10.1159/000241689

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Our results indicate that more than 50% of particles are This particular picture of lipoproteins and apolipoproteins is similar to those reported in pigs [20] and rats [3], However, these obser vations are in contrast with those made in human fetuses, which present a high HDL/LDL ratio [21 ]. In another small rumi nant species, the sheep, Noble and Shand [22] reported that HDL was the major lipoprotein fraction both in the mother and in the fetal lamb. Nevertheless, they used only final ges tational fetuses.…”

Section: Discussionmentioning

confidence: 99%

Developmental Changes in Plasma Apolipoproteins B and A-I in Fetal Bovines

Marcos¹,

Mazur²,

Cardot³

et al. 1991

Neonatology

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Plasma lipid, apolipoprotein (apo) B and apo A-I concentrations were measured in fetal calves in the age range of 4–9 months. The results were compared with those obtained from preruminant calves and cows. The studied lipids and apolipoproteins underwent quantitative changes during development. Fetal calves, as compared to preruminant calves and cows, had a particularly low apo A-I concentration and a high apo B/apo A-I ratio. Unlike adult animals which have two forms of apo B, fetal calves had only high molecular weight apo B (apo Bh). During fetal development triglyceride, cholesterol and apo B concentrations decreased, but apo A-I concentrations remained constant.

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Section: Discussionmentioning

confidence: 99%

Developmental Changes in Plasma Apolipoproteins B and A-I in Fetal Bovines

Marcos¹,

Mazur²,

Cardot³

et al. 1991

Neonatology

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“…The composition of the LP may also be different between fetuses and adults [3][4][5][6], Studies with premature human infants and infants delivered by caesarean section suggest that the human fetus also has serum lipid levels considerably lower than adult levels [7][8][9]. Detailed analyses of scrum lipids and LP at early stages of fetal development, however, are rare in animals, and for ethical reasons, difficult to obtain in humans.…”

Section: Introductionmentioning

confidence: 99%

Serum and Lipoprotein Lipids of Fetal Pigs and Their Dams during Gestation as Compared with Man

Hentges¹,

Martin²

1987

Neonatology

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Serum and lipoprotein (LP) lipids were measured in fetal pigs and their dams during gestation. In the 2nd trimester (70 days of gestation), fetal lipids resembled those of their dams. Early in the 3rd trimester (90 days) total serum concentrations of cholesterol (CH), triglyceride (TG) and free fatty acids (FFA) were lower in fetuses than in sows (p < 0.01), but the decreases were not expressed uniformly among the LP classes. By the middle of the 3rd trimester (100 days) fetal serum lipids had declined further, and the distribution of TG (but not CH) between the LP fractions was significantly different from the distribution in sows (p < 0.01). Sow serum CH, TG and FFA varied, but did not change significantly from days 70 to 100 of gestation; there was a tendency for sow serum lipids to increase, particularly FFA. Distributions of TG and CH in sow LP were unchanged by pregnancy. Results suggest that independent fetal regulation of lipid metabolism develops during the last half of gestation, and that lipid metabolism (especially TG) may be altered during fetal life. Changes in sow lipids during gestation were much less pronounced than in humans, but fetal patterns were similar.

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A comparison of the lipid compositions of the lipoproteins of the intestinal and popliteal lymph and plasma of sheep

et al. 1984

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The lipids and lipoproteins of intestinal lymph in the sheep make a contribution to the corresponding fractions in plasma and thence affect lipid compositions in other tissues. As a first step towards assessing this contribution, the lipoproteins of intestinal lymph, peripheral (popliteal lymph) and plasma have been isolated for compositional studies. Popliteal lymph and the plasma were similar in the distributions of lipids among the major lipoprotein fractions with high-density lipoproteins accounting for just over half of the total lipid present. In intestinal lymph, 80 per cent of the total lipid was associated with the very low-density lipoprotein fraction. Whereas triacylglycerols comprised the principal lipid component of the very low-density lipoprotein and low-density lipoprotein fractions of the intestinal lymph and were present in the high-density lipoprotein fraction, they were present in essence only in the very low-density lipoprotein fraction of popliteal lymph and plasma, where high concentrations of cholesteryl esters and phospholipids were found in all the lipoprotein fractions. The fatty acid compositions of each lipid class were also determined. The most distinctive feature of the results was the distribution of the essential fatty acid, linoleic acid, among the lipid components. In all lipid classes in each of the body fluids, the concentration of this component was highest in the high-density lipoproteins and lowest in the very low-density lipoproteins. Higher concentrations tended to be present in the triacylglycerols and phosphatidylcholine fractions of intestinal lymph than of plasma and popliteal lymph, but the opposite was true of the cholesteryl esters. The results are discussed in terms of the sources of the linoleic acid in the lipids of intestinal lymph of ruminant animals.

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A Comparative Study of the Distribution and Fatty Acid Composition of the Lipoproteins in the Fetal and Maternal Plasma of Sheep

Cited by 5 publications

References 16 publications

Developmental Changes in Plasma Apolipoproteins B and A-I in Fetal Bovines

Developmental Changes in Plasma Apolipoproteins B and A-I in Fetal Bovines

Serum and Lipoprotein Lipids of Fetal Pigs and Their Dams during Gestation as Compared with Man

A comparison of the lipid compositions of the lipoproteins of the intestinal and popliteal lymph and plasma of sheep

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