A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis

Islam, Shabiul; Ahmed, Kh Tanvir; Manik, M.K.; Wahid, Md. Arif; Kamal, Chowdhury Shafayat Ibne

doi:10.1016/s2221-1691(13)60139-2

Cited by 56 publications

(41 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Outras plantas da família Anacardiaceae têm sido avaliadas sobre sua ação antimicrobiana, Spondias dulcis e Schinopsis brasiliensis foram avaliadas com relação a essa atividade seguindo a mesma metodologia deste estudo, e mostraram-se ativas contra as bactérias S. aureus e E. coli [38].…”

Section: Resultsunclassified

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Santos

Marisco

2017

Sci. Plena

View full text Add to dashboard Cite

_____________________________________________________________________________O uso de plantas medicinais cada vez mais é mostrado como uma fonte alternativa para tratamento de doenças. Este trabalho visou determinar o nível genotóxico e citotóxico da infusão das folhas de Spondias purpurea L., investigar o potencial antimicrobiano e conhecer o perfil cromatográfico de compostos presentes na infusão. Foram realizados os testes Allium cepa e Artemia salina para avaliar a genotoxicidade e citotoxicidade, respectivamente. Os métodos de difusão em disco e concentração inibitória mínima (CIM) foram usados para determinar a atividade antibacteriana nas bactérias Staphylococcus epidermidis, S. aureus, Escherichia coli, Salmonella enterica sorotipo Choleraesuis, Pseudomonas aeruginosa e Klebsiella pneumoniae. No teste de A. cepa, a análise estatística não indicou diferenças significativas do índice mitótico entre os tratamentos e o controle. O teste de A. salina mostrou que a infusão apresentou toxicidade frente aos náuplios a partir da dose 10µg/mL. Em relação à atividade antibacteriana, houve presença de halos de inibição contra as bactérias S. aureus e E. coli, e quando submetidos ao CIM, a infusão apresentou atividade antibacteriana contra todas as bactérias testadas. Sendo assim, a partir desse estudo pode-se inferir que a infusão (chá) das folhas da planta S. purpurea se mostrou como uma fonte medicinal não genotóxica para o teste A. cepa, bem como uma possível fonte antitumoral indicada pelo teste A. salina, além de uma promissora fonte antibacteriana.Palavras-chaves: Genotoxicidade, Antimicrobiana, Seriguela.The use of medicinal plants is increasingly shown as an alternative source for the treatment of diseases. This study aimed to determine the level genotoxic and cytotoxic infusion of the leaves of Spondias purpurea L., study the antimicrobial potential and know the chromatographic profile of the compounds present in the infusion. Tests were performed Allium cepa and Artemia salina to assess the genotoxicity and cytotoxicity, respectively. The disk diffusion method and the minimum inhibitory concentration (MIC) they were used to determine the antibacterial activity in bacteria Staphylococcus epidermidis, S. aureus, Escherichia coli, Salmonella enterica serotype Choleraesuis, Pseudomonas aeruginosa e Klebsiella pneumoniae. On test A. cepa, statistical analysis indicated no significant differences in mitotic index between treatment and control. The test of A. salina showed that infusion toxicity has opposite from the nauplii dose 10mg / ml. With regard to antibacterial activity, there was the presence of halos of inhibition against the bacteria S. aureus e E. coli, and when subjected to MIC infusion showed antibacterial activity against all tested bacteria. Thus, from this study can be inferred that the infusions (tea) from the plant leaves S. purpurea showed as a non-genotoxic medicinal source for testing A. cepa, as well as a possible antitumor source indicated by the test A. salina, as well as a promising anti...

show abstract

Section: Resultsunclassified

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Santos

Marisco

2017

Sci. Plena

View full text Add to dashboard Cite

show abstract

“…In the study by Islam et al (2013), when determining the content of phenolic compounds in caja-manga, the authors obtained the following values for the methanolic and chloroform extract: 659.74 and 214.59 mg GAE g -1 dried fruit, respectively. The lower TP of this work may be related to the fact that a pulp was used instead of a dried fruit such as in Islam et al (2013).…”

Section: Determination Of Phenolic Compounds and Antioxidant Capacitymentioning

confidence: 99%

Physicochemical, antioxidant and sensory properties of fermented milk beverage with added prebiotic and caja-manga pulp

et al. 2018

View full text Add to dashboard Cite

The objective of the study was to evaluate the physicochemical, antioxidant and sensory properties of fermented milk beverage with added prebiotic and caja-manga pulp. Three milk beverage formulations were prepared, with 25% and 30% caja-manga pulp and a control (pulp-free) formulation. The following were evaluated: physicochemical characteristics (pH, acidity, proximal composition, color), total phenolics, antioxidants (DPPH, ABTS, FRAP), and sensory properties (preference, acceptance, and purchase intention). Differences were observed between the beverages regarding the physicochemical characteristics, and the composition varied according to the pulp concentration added. The beverages with pulp presented higher phenolic content than control formulation. The formulations with 25% and 30% pulp presented antioxidant capacity by the DPPH method with no significant difference between them. However, it was not possible to observe the antioxidant capacity of the pulp-free beverage for this method. No antioxidant capacity was detected by the ABTS and FRAP methods for all beverages studied. The milk beverages presented good sensory acceptance and antioxidant capacity due to the bioactive compounds present in the caja-manga pulp, which contributes to the claim of functionality of this food.Additional keywords: total phenolics; oligofructose; fermented product; Spondias dulcis. ResumoO objetivo do estudo foi avaliar as propriedades físico-químicas, antioxidantes e sensoriais de bebida láctea fermentada adicionada de prebiótico e polpa de cajá-manga. Três formulações de bebida láctea foram preparadas com 25% e 30% de polpa de cajá-manga e uma formulação-controle (isenta de polpa). Foram avaliadas as características físico-químicas (pH, acidez, composição proximal e cor), fenólicos totais, antioxidantes (DPPH, ABTS e FRAP) e sensoriais (preferência, aceitação e intenção de compra). Foram observadas diferenças entre as bebidas quanto às características físico-químicas, sendo que a composição variou de acordo com a concentração de polpa adicionada. As bebidas com polpa apresentaram maior teor de fenólicos que a formulação-controle. As formulações com 25% e 30% de polpa apresentaram capacidade antioxidante pelo método DPPH sem diferença significativa entre si. Entretanto, não foi possível observar capacidade antioxidante da bebida sem polpa para este método. Não foi detectada capacidade antioxidante pelos métodos ABTS e FRAP para todas as bebidas estudadas. As bebidas lácteas apresentaram boa aceitação sensorial e capacidade antioxidante decorrente dos compostos bioativos presentes na polpa de cajá-manga, o que contribui para a alegação de funcionalidade deste alimento.Palavras-chave adicionais: fenólicos totais; oligofrutose; produto fermentado; Spondias dulcis.

show abstract

“…This assay was determined by Griess Illosvoy reaction using sodium nitroprusside [24] . 0.5 ml of extract fractions (ETH, EDI, CTH and CDI) at various concentrations (25, 50, 75,100,250 µg/ml) was mixed with 2 ml of 10 mM sodium nitroprusside in 0.5 ml phosphate buffer saline (pH 7.4) and incubated at 25°C for 150 minutes.…”

Section: Nitric Oxide Scavenging Assaymentioning

confidence: 99%

Comparative Evaluation of Crude Extract Fractions of the Whole Plant of Taxillus heyneanus and Dalechampia indica for Antioxidant Activity, Total Phenolic and Flavonoid Content

S¹,

Eswaraiah²

2017

IOSRPHR

View full text Add to dashboard Cite

This study was aimed to investigate the total phenolic content (TPC), total flavonoid content (TFC) and antioxidant potential of ethanolic fraction (ETH&EDI) and chloroform fraction (CTH & CDI) of crude extracts of the whole plant of Taxillus heyneanus (TH) and Dalechampia indica (DI). values (38.75 ±0.83, 62.67±5.23, 80.89±0.47μg ⁄ ml values(477.61±0.69, 404.00±0.38 & 505.52±4.83 μg ⁄ml) values for the DPPH, Hydrogen peroxide and nitric oxide. Ethanolic fractions of both plants (ETH & EDI) exhibited significant scavenging activities with good amounts of phenolic and flavonoid compared to its chloroform fractions (CTH & CDI).The results of the study show that ethanolic fraction of Taxillus heyneanus possesses better antioxidant activity compared to the ethanolic fraction of Dalechampia indica which could be attributed to the presence of high amount of phenolic and flavonoids. Keywords: Antioxidant activities, Dalechampia indica, Taxillus heyneanus, whole plant I. INTRODUCTOIONThe human body is a wonderful machine which requires fuel named oxygen for its function. It plays a pivotal role in the energy metabolism of the body which involves various physical and chemical processes [1] .While oxygen supports our life, it also produces free radicals (ROS) in the body as the waste products. Oxygencentered free radicals (ROS) includes superoxide anion (O 2 .-), hydroxyl radical (.OH), hydrogen peroxide (H 2 O 2 ), peroxyl, hypochlorous acid and nitric oxide [2] . These are highly reactive unstable molecules which have a hunger for electrons, reacts with biomolecules (lipids, proteins, DNA etc.) and alters its structure and function. This, in high levels, leads to oxidative stress [3,4] .Oxidative stress occurs when our body defense systems fail to wipe off this excess amount of free radicals. These free radicals spring from different sources such as endogenous (mitochondria, peroxisomes, endoplasmic reticulum etc.) and exogenous (pollution, ionization radiation etc.) sources [5] .It has implications for a broad range of disorders including stroke, ischemia-reperfusion injury, arthritis, cancer, diabetes, neurodegenerative diseases, spinal cord injury, cardiovascular diseases, sepsis, inflammation and respiratory diseases [6,7] .Here comes the concept of antioxidants, nature's way of cell defense against free radical (ROS) attack. These antioxidants synthesized invivo (SOD, catalase, glutathione peroxidase) or taken as dietary antioxidants (vitamin C, vitamin E, β-carotene and selenium) either quenches or scavenges free radicals (ROS) and repairs the damages caused by them [8] .The quest for effective and beneficial natural antioxidants has been increased nowadays as the synthetic antioxidants like butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) found to be harmful [9] .Plants are found to be a good source of natural antioxidants as they can synthesize phytoconstituents such as phenolics, tannins, flavonoids etc. in different parts which have the ability to scavenge free radicals [10].T...

show abstract

A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis

Cited by 56 publications

References 40 publications

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Avaliação da atividade genotóxica, citotóxica e antimicrobiana da infusão das folhas de Spondias purpurea L.

Physicochemical, antioxidant and sensory properties of fermented milk beverage with added prebiotic and caja-manga pulp

Comparative Evaluation of Crude Extract Fractions of the Whole Plant of Taxillus heyneanus and Dalechampia indica for Antioxidant Activity, Total Phenolic and Flavonoid Content

Contact Info

Product

Resources

About