A comparative study of the buffering capacity of various commercially available gastric antacids

Antacid therapy of peptic ulcer: Part II An evaluation of antacids in vitro

“…Methods of assessing the potency of antacids in the past have consisted of two general classes: those that involve the periodic removal of a small volume of reaction mixture and the subsequent addition of an equal volume of acid solution (Johnson and Duncan, 1945;Hefferren, Schrotenboer, and Wolman, 1956) and those that involve only the addition of fresh hydrcchloric acid (Hammarlund and Rising, 1949;Dale and Booth, 1955). In these methods, the pH of the reaction mixture was determined every few minutes for intervals of three hours (Hammarlund and Rising 1949) or until the pH reached 1 8;…”

“…The method used differed from that of previous studies (Johnson and Duncan, 1945;Hammarlund and Rising, 1949;Dale and Booth, 1955) in that a known amount of antacid preparation was added to 25.0 ml. of distilled water and titrated to pH 4 5 with N/10HC1 solution at room temperature.…”

Studies on Powdered Preparations. VII. Acid Neutralizing Velocity of Antacids

“…Equation (2) indicates that the velocity is proportional to the amount of acid adsorbed on the surface of antacid powder,which is empirically related by the Freundlich type isotherm. Similar proportionality is found in some of the heterogeneous catalytic reaction.…”