Context: Emotion regulation problems are increasingly recognized as an underlying mechanism of many disorders. Dialectical behaviour therapy (DBT) holds potential as an effective transdiagnostic treatment for disorders with underlying emotion regulation deficits.Objective: Systematically review the evidence for DBT Skills Training Groups as a transdiagnostic treatment for Axis I disorders via meta-analysis. Study Selection: Randomized control trials of DBT Skill Training Groups for adults with Axis I disorders, and no comorbid Axis II disorder, were included. Data Synthesis: Thirteen RCTs met inclusion criteria (N = 515 participants). Overall, DBT resulted in a moderate effect on symptom reduction (g = 0.51, 95% CI [0.32, 0.70], p < .001). Improvements on emotion regulation outcomes yielded a small-to-moderate effect (g = 0.42, 95% CI [0.10, 0.74], p < .01). Results showed significant effects of DBT on depression (g = 0.44, 95% CI [0.23, 0.65], p < .01) and eating disorders (g = 0.83, 95% CI [0.49, 1.17], p = .001) but not for anxiety (g = 0.35, 95% CI [-0.07, 0.77], p > .08).Conclusions: Findings suggest DBT is an effective treatment for multiple Axis I disorders characterised by underlying emotion regulation deficits and many be considered as a promising transdiagnostic therapy.