A Comparative Study of the Chemical Stability of Various Mitomycin C Solutions Used in Glaucoma Filtering Surgery

Solubilization and Stability of Mitomycin C Solutions Prepared for Intravesical Administration

“…Based on the literature, the solubility of MMC at room temperature prepared in water and various other aqueous milieu is approximately 0.9 mg/mL [28–30]. Nonetheless, in certain bladder cancer patients, urology surgeons utilize MMC preparations in concentrations ≥1 mg/mL [7], which supersede its solubility threshold.…”

LC-ESI-MSD fast determination of residual mitomycin C in hen aqueous humour after corneal refractive surgery

“…The drug binds with proteins, so this could promote long-term toxicity effects because its elimination is difficult. In other ocular applications, the above-mentioned toxicity has been reported [6][7][8][9].…”

“…For this reason, it is very common to use some preconcentration steps, preferably by solid phase extraction, although other options have also been proposed, most of them including a step of protein elimination [16][17][18][19]. In ophthalmology, MMC has been used as a complementary therapy in trabeculectomy and glaucoma filtering surgery [6,7] and that is the reason why there are some papers devoted to drug determination in ocular tissues and fluids [20][21][22][23] trying to establish the optimal concentration in MMC application. Those papers, in general, lack analytical considerations because in some instances, the calibration is made on aqueous standards, and therefore, interferences are not usually considered, identification is carried out only on the basis of retention time and protein effect is ignored.…”

The Degradation of Mitomycin C Under Various Storage Methods

“…[1][2][3][4][5][6][7][8][9][10][11] However, prior stability results have been inconsistent, that is, 1 study found refrigerated MMC unstable after 24 hours, however, a separate study found it stable at 28 days. [1][2][3][4][5][6][7][8][9][10][11] However, prior stability results have been inconsistent, that is, 1 study found refrigerated MMC unstable after 24 hours, however, a separate study found it stable at 28 days.…”

“…[1][2][3][4][5][6][7][8][9][10][11] However, prior stability results have been inconsistent, that is, 1 study found refrigerated MMC unstable after 24 hours, however, a separate study found it stable at 28 days. 4,5,8,10 In addition to testing this threshold, we also identified degradation products that could potentially influence the conjunctiva and affect outcomes. For example, in clinical practice MMC may be shipped from an independent compounding pharmacy, thawed, and kept at room temperature before application, or compounded in the operating room from dry powder.…”