A comparative study of the incidence of aseptic meningitis in symptomatic natural mumps patients and monovalent mumps vaccine recipients in Japan

Nagai, Takao; Okafuji, Teruo; Miyazaki, Chiaki; Ito, Yuhei; Kamada, Makoto; Kumagai, Toshiko; Yuri, Kenji; Sakiyama, Haruhiko; Miyata, Akiko; Ihara, Toshiaki; Ochiai, Hitoshi; Shimomura, Kunihisa; Suzuki, Eitaro; Torigoe, Sadayoshi; Igarashi, Masahiro; Kase, Tetsuo; Okuno, Yoshinobu; Nakayama, Tetsuo

doi:10.1016/j.vaccine.2005.11.068

Cited by 50 publications

(26 citation statements)

References 16 publications

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“…Therefore, we always explain these two cases to the parents of new vaccine candidates. Self-limited swelling of the parotid glands after mumps immunization (3.9%, 2/51) was similar to the rate previously reported among healthy vaccinees (3.5%) [23]. Recent reports regarding immunization for post-liver transplant patients also showed no related serious adverse events [5][6][7][8].…”

Section: Undeterminedsupporting

confidence: 84%

Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation

Shinjoh

Hoshino

Takahashi

et al. 2015

Vaccine

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Section: Undeterminedsupporting

confidence: 84%

Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation

Shinjoh

Hoshino

Takahashi

et al. 2015

Vaccine

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“…Around 1% to 5% of patients with parotitis will develop meningitis; the incidence of encephalitis is believed to be smaller 21 . Normally, mumps encephalitis develops 5 days after the onset of parotitis.…”

Section: Mumpsmentioning

confidence: 99%

Viral encephalitis

Silva

2013

Arq. Neuro-Psiquiatr.

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While systemic viral infections are exceptionally common, symptomatic viral infections of the brain parenchyma itself are very rare, but a serious neurologic condition. It is estimated that viral encephalitis occurs at a rate of 1.4 cases per 100.000 inhabitants. Geography is a major determinant of encephalitis caused by vector-borne pathogens. A diagnosis of viral encephalitis could be a challenge to the clinician, since almost 70% of viral encephalitis cases are left without an etiologic agent identified. In this review, the most common viral encephalitis will be discussed, with focus on ecology, diagnosis, and clinical management.

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“…In Japan, MMR vaccine was administered between 1989 and 1993, but discontinued because of an unexpectedly high incidence of aseptic meningitis [Ueda et al, 1995;Kimura et al, 1996]. Since 1993, a monovalent mumps vaccine has been used but vaccine coverage is estimated to be less than 30% [Nagai et al, 2007]. Mump virus is still circulating worldwide and some clinically apparent mumps patients had a clinical history of previous infection or immunization [Utz et al, 2004;WatsonCreed et al, 2006].…”

Section: Introductionmentioning

confidence: 99%

Mumps virus reinfection is not a rare event confirmed by reverse transcription loop‐mediated isothermal amplification

Yoshida

Fujino

Miyata

et al. 2008

Journal of Medical Virology

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Clinically apparent mumps reinfection is considered extremely rare, but several cases have been suspected of reinfection in an out-patient clinic. In this study, virological examination, virus isolation, the reverse transcription loop-mediated isothermal amplification (RT-LAMP), and IgG and IgM EIA antibodies, were examined in order to identify mumps reinfection. Patients were divided into three categories; the reinfection group comprised 29 patients with a history of natural infection, the vaccine-failure group consisted of 37 patients with an immunization history, and two patients had histories of both immunization and mumps infection. Another 25 patients were enrolled as a primary infection group. Mumps virus was isolated in 5 (17%) and the genome was detected in 12 (41%) of 29 in the reinfection group. Reinfection was confirmed in 21/28, demonstrating high avidity of IgG EIA. Mumps virus was isolated in 15 (41%) and there was a higher positivity of genome amplification in 25 (68%) of 37 patients in the vaccine-failure group. Among these, 23 were confirmed as secondary vaccine failure by high avidity IgG EIA serology. In the primary infection group, the isolation rate and genome detection rate was higher in 16 (64%) and in 18 (72%) of 25 patients, respectively. There was no significant difference in virus load among the three groups but high mumps virus load was suspected in the IgM EIA-positive group based on the shorter amplification time on RT-LAMP. Mumps virus reinfection was confirmed by RT-LAMP and an IgG avidity test and was not a rare event.

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A comparative study of the incidence of aseptic meningitis in symptomatic natural mumps patients and monovalent mumps vaccine recipients in Japan

Cited by 50 publications

References 16 publications

Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation

Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation

Viral encephalitis

Mumps virus reinfection is not a rare event confirmed by reverse transcription loop‐mediated isothermal amplification

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