A comparative study of the cardiac innervation in domestic animals: sheep

McKibben, John Scott; Getty, R.

doi:10.1159/000143379

Cited by 15 publications

(14 citation statements)

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“…The left cardiothoracic nerves innervate the left and right ventricular muscle, the left atrium and septum, and the sinoatrial and atrioventricular nodes (34,46). Briefly, an incision was made above the fourth rib, the periosteum was opened, and the rib was removed.…”

Section: Methodsmentioning

confidence: 99%

Increased cardiac sympathetic nerve activity in heart failure is not due to desensitization of the arterial baroreflex

Watson¹,

Hood²,

Ramchandra³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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Increased sympathetic drive to the heart worsens prognosis in heart failure, but the level of cardiac sympathetic nerve activity (CSNA) has been assessed only by indirect methods, which do not permit testing of whether its control by arterial baroreceptors is defective. To do this, CSNA was measured directly in 16 female sheep, 8 of which had been ventricularly paced at 200-220 beats/min for 4-6 wk, until their ejection fraction fell to between 35 and 40%. Recording electrodes were surgically implanted in the cardiac sympathetic nerves, and after 3 days' recovery the responses to intravenous phenylephrine and nitroprusside infusions were measured in conscious sheep. Electrophysiological recordings showed that resting CSNA (bursts/100 heartbeats) was significantly elevated in heart-failure sheep (89 +/- 3) compared with normal animals (46 +/- 6; P < 0.001). This increased CSNA was not accompanied by any increase in the low-frequency power of heart-rate variability. The baroreceptor-heart rate reflex was significantly depressed in heart failure (maximum gain -3.29 +/- 0.56 vs. -5.34 +/- 0.66 beats.min(-1).mmHg(-1) in normal animals), confirming published findings. In contrast, the baroreflex control of CSNA was undiminished (maximum gain in heart failure -6.33 +/- 1.06 vs. -6.03 +/- 0.95%max/mmHg in normal sheep). Direct recordings in a sheep model of heart failure thus show that resting CSNA is strikingly increased, but this is not due to defective control by arterial baroreceptors.

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Section: Methodsmentioning

confidence: 99%

Increased cardiac sympathetic nerve activity in heart failure is not due to desensitization of the arterial baroreflex

Watson¹,

Hood²,

Ramchandra³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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“…Yet, to our knowledge, the topography and architecture of the ovine cardiac neural plexus have been reported by only one published article to date 23. Therefore, we aimed at (1) ascertaining both the topography and architecture of the ovine epicardial neural plexus (ENP); (2) determining the relationships of ENP with the vagal and sympathetic cardiac nerves and ganglia; and (3) evaluating gross anatomical differences and similarities of ENP in sheep, humans and other species with the objective of determining the suitability of the sheep heart as a model in experimental cardiac electrophysiology and surgery.…”

Section: Introductionmentioning

confidence: 99%

Epicardial neural ganglionated plexus of ovine heart: Anatomic basis for experimental cardiac electrophysiology and nerve protective cardiac surgery

et al. 2010

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“…Detailed gross observations of the cardiac innervation of domestic animals are well documented in several textbooks (Miller, 1964;Sisson and Grossman, 1964;Dursun, 2000) and papers (McKibben and Getty, 1968, 1969a, 1970Phillips et al, 1986). Studies have indicated that both the right and left cardiac plexuses receive extrinsic sympathetic nerves in these animals from the cranial and caudal thoracic cardiac nerves Getty, 1968, 1969a;Brugnaro et al, 2003), the stellate ganglion through the ansa subclavia Getty, 1969b, 1970), and the vertebral and middle cervical ganglia (McKibben and Getty, 1970;Brugnaro et al, 2003).…”

Section: Introductionmentioning

confidence: 96%

Extrinsic Cardiac Nerve Distribution in Goitred Gazelle (Gazella subgutturosa)

et al. 2005

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Extrinsic cardiac nerves and their patterns are described based on anatomical dissections of five goitred gazelle. Sympathetic cardiac innervation was mainly provided by the cervicothoracic and thoracic cardiac nerves. No left caudal cervicothoracic nerves, middle cervical cardiac nerves and vertebral cardiac nerves from the vertebral ganglion were observed. Parasympathetic cardiac innervation was supplied by the nerve fibres from the caudal vagal cardiac rami only. No cardiac rami from the cranial vagal cardiac nerves present in small ruminants were observed in this study. The caudal laryngeal and phrenic cardiac nerves also contributed to the cardiac innervation.

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A comparative study of the cardiac innervation in domestic animals: sheep

Cited by 15 publications

References 0 publications

Increased cardiac sympathetic nerve activity in heart failure is not due to desensitization of the arterial baroreflex

Increased cardiac sympathetic nerve activity in heart failure is not due to desensitization of the arterial baroreflex

Epicardial neural ganglionated plexus of ovine heart: Anatomic basis for experimental cardiac electrophysiology and nerve protective cardiac surgery

Extrinsic Cardiac Nerve Distribution in Goitred Gazelle (Gazella subgutturosa)

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