“…The method allows processing of plant material at low temperatures, thereby avoiding thermal degradation, and supercritical CO 2 is cheap, inert, environmentally friendly, nontoxic, and generally regarded as safe by the FDA [103,104]. The technique is mainly employed for the extraction of bioactive nonpolar compounds, like lipids, carotenoids, and essential oils [100]; in order to extract more polar compounds such as flavonoids, lignans, and simple phenolics, small amounts of modifiers like ethanol, methanol, acetone, and water have to be added [103,104]. Further methods involving pressurized liquids, like pressurized liquid extraction (PSE) or pressurized hot water extraction, are also frequently used for extraction of herbal material but not yet well established in an industrial scale [61,103].…”