A Comparative Study on Effect of Fentanyl With Propofol and Fentanyl With Dexmedetomidine as Intravenous Anaesthetics for Upper Gi Endoscopy

Abstract

BACKGROUND Routine upper GI endoscopy is the standard practice to diagnose oesophageal, gastric and duodenal diseases. The Upper GI Endoscopy may be performed with or without conscious sedation using topical pharyngeal anaesthesia alone. But patient's tolerance to procedure and endoscopist satisfaction increases when sedation is used along with topical pharyngeal anaesthesia. 1 The present study is to compare the haemodynamic effects and sedation efficacy of fentanyl with propofol and fentanyl with dexmedetomidine in patients undergoing elective diagnostic upper gastrointestinal endoscopy (UGIE). MATERIALS AND METHODS This is a randomized prospective comparative study. It was undertaken at Viswabharathi Hospital, Kurnool among 60 patients during the period of October 2014 to October 2016. RESULTS The patients were assigned into two groups of 30 each. Group P (n=30) received Propofol to achieve desired level of sedation and Group D (n=30) received Dexmedetomidine. There was statistically significant difference between groups with regard to induction time, recovery time and endoscopist satisfaction (p <0.05). Induction time was shorter in propofol group when compared to dexmedetomidine group (0.79 min vs 10.73 min, p=0.0001). Endoscopist satisfaction is also significantly higher in dexmedetomidine group when compared to propofol group (0.9 vs. 1.82, p =0.0001). CONCLUSION Use of dexmedetomidine was associated with greater haemodynamic stability and faster recovery when compared to propofol. Endoscopists expressed a higher level of satisfaction with dexmedetomidine compared with propofol.