A comparative study on efficacy of different treatment modalities of oral submucous fibrosis evaluated by clinical staging in population of Southern Rajasthan

Goel, Sandeep; Ahmed, Junaid

doi:10.4103/0973-1482.139263

Cited by 25 publications

(14 citation statements)

References 16 publications

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“…Thirty subjects were given 8 mg lycopene twice daily, and after a follow‐up period of 9 months, mean value of difference in VAS score, mouth opening, tongue protrusion, and cheek flexibility (pre‐ & post‐treatment) was found to be 5.0 ± 2.3, 4.1 ± 4.2 mm, 2.4 ± 3.5 mm, and 0.66 ± 0.80 mm, respectively, and were found to be concordant with findings observed in other studies (Goel & Ahmed, ; Kumar, Bagewadi, Keluskar, & Singh, ). However other criteria of tongue protrusion and check flexibility were not taken into consideration in the previous study.…”

Section: Discussionsupporting

confidence: 89%

Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial

et al. 2018

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Section: Discussionsupporting

confidence: 89%

Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial

et al. 2018

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“…Various studies are stated in the literature with significant mean improvement in mouth opening using levamisole (2.9 mm), antoxid (3.1 mm), lycopene (3.4 mm, 5.38 mm), lycopene with Vitamin E (6.2 mm), pentoxifylline (7 mm), pentoxifylline with garlic pearls (5 mm), turmeric with tulsi (3–4 mm), and turmeric with black pepper (3.8 mm). [81416171819] Group A patients in the present study have shown equivalent results to antoxid, levamisole, turmeric with tulsi, and turmeric with black pepper. Group B patients have shown comparable results to lycopene, lycopene with Vitamin E, and pentoxifylline with garlic pearls.…”

Section: Discussionsupporting

confidence: 54%

Efficacy of spirulina along with different physiotherapeutic modalities in the management of oral submucous fibrosis

Kanjani

Annigeri

Revanappa

et al. 2019

Ann Maxillofac Surg

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Context: Oral submucous fibrosis (OSMF) is an insidious, chronic, disabling disease that mainly affects the oral mucosa. Spirulina is a freshwater microalga which is considered as superfood by the WHO. Due to its antioxidant, anti-inflammatory, and immunomodulating properties, spirulina has shown promising results in the management of OSMF. A wide range of treatment modalities have been tried ranging from medical, physical, or surgical interventions, but combinations of these have shown better results. Aims: The study aimed to evaluate the efficacy of spirulina along with different physiotherapeutic modalities in the management of OSMF. Setting and Design: The present comparative study was conducted in the Department of Oral medicine and radiology, College of Dental Sciences, Davangere, Karnataka, India. The block randomization technique was used in the present study to enroll patients into three different groups. Methods: The study consisted of 45 OSMF patients who were divided randomly into three groups. All patients were given spirulina 500 mg twice a day for 3 months. Group A patients were instructed to perform isometric mouth exercises for 20 min, twice daily. Group B patients and Group C patients perform exercises using threaded tapered screw and mouth stretching device (MSD), respectively, ten times bilaterally twice a day. Clinical parameters such as burning sensation, mouth opening, tongue protrusion, and cheek flexibility were assessed every 15 days. Statistical Analysis Used: Descriptive data that included mean, numbers, and percentages were calculated for each group and were used for analysis. For intra- and inter-group comparison, paired t- and unpaired t -test was used, respectively. For all the tests, P = 0.05 or less was considered for statistical significance. Results and Conclusion: All the groups have shown statistically significant improvement in burning sensation, mouth opening, tongue protrusion, and cheek flexibility ( P < 0.05). Group C patients have shown better results followed by Group B and Group A patients. In the present study, spirulina along with different physiotherapeutic modalities was well tolerated by the patients, and significant improvement was seen in the MSD group.

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“…[36] on levamisole; Haque et al . [37] on interferon gamma; Goel and Ahmed[38] and Gupta et al . [39] on steroids; Khanna and Andrade et al .…”

Section: Treatments In Practicementioning

confidence: 99%

A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach

Gavli

Han

et al. 2018

J Oral Maxillofac Pathol

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Oral submucous fibrosis (OSMF) is a chronic, progressive, debilitating, scarring and crippling disorder of the oral cavity. It is a potentially malignant oral disease which predominantly affects people of South and Southeast Asia, especially Indian subcontinent, where chewing of areca nut and its commercial preparation is rampant. However, due to increase in immigration of people from the Indian subcontinent, the health professionals in many developed countries do come across this disease very often. Since decades, many treatment modalities are suggested and studied using medicines, surgery and physiotherapy, with varying degrees of benefit, but none have been able to cure this disease completely, and hence, it has become a challenging condition. The present article emphasizes on various therapeutic interventions used till date to curb the menace of this disease and the principal author with his vast academic research and clinical experience in treating this disease has proposed the stage-wise treatment regimen for OSMF. The current article is an attempt to compile the available treatment, its current status and future perspectives, so as to assist early intervention of the disease with evidence-based approach. This article will ignite the research minds of dental clinician, oral medicine specialist, otolaryngologist and general physician in treating OSMF.

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A comparative study on efficacy of different treatment modalities of oral submucous fibrosis evaluated by clinical staging in population of Southern Rajasthan

Abstract: It is evident from the study that capsule lycopene and injection betamethasone hold good promise in the treatment of this multifactorial crippling disease.

Cited by 25 publications

References 16 publications

Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial

Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial

Efficacy of spirulina along with different physiotherapeutic modalities in the management of oral submucous fibrosis

A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach

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