A comparative study on Naproxen Sodium tablets formulating with different super disintegrants

Kayes, Sikdar K M Yasif; Molla, Md. Islam; Hamidur, Rahman Md; Saqueeb, Nazmus

doi:10.30574/gscbps.2019.9.3.0234

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Different kinetics models like Higuchi, Hixson-Crowell, zero order and first order models were performed to determine the drug release kinetics of the ternary solid dispersion formulations (Kayes et al, 2019). Moreover, one way analysis of variance (ANOVA) was performed among the optimized physical mixing (PM) and solid dispersions (SD) formulations for determining how the drug released significantly from these formulations.…”

Section: Drug Release Kinetics Analysismentioning

confidence: 99%

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Sarkar¹,

Hossin²,

Hossain³

et al. 2021

Bangladesh J. Sci. Ind. Res.

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Atorvastatin calcium (ATV) is an HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitor commonly known as a cholesterol-lowering agent. As a poorly water-soluble drug its absolute bioavailability is very low. To increase the water solubility as well as oral bioavailability, different hydrophilic carriers were used in different ratios (1:0.5, 1:1 and 1:2) to prepare reproducible binary and ternary solid dispersion formulations of ATV by simple physical mixing (PM) and fusion or melting technique. In vitro dissolution studies results revealed that in all cases, the cumulative percent drug release from ATV ternary SD formulations were greater than binary formulations, some marketed products and pure ATV powder. The order of the carriers in enhancing the drug release was found as kollidon 90F > pregelatinized starch > lutrol> kollidon 12F (99.1%, 98.8%, 96% and 95% respectively) for ternary SD formulations whereas pure ATV powder and marketed products showed cumulative percentage release 70.8%, 68.9% (B1) and 73.1% (B2), respectively. The best-out performed ternary SD formulation ATV:Kollidon 90 F (1:2) were further characterized using FT-IR and SEM. SEM analyses indicated conversion of crystal drug to amorphous form and FT-IR data suggested that little or no interaction between the drug and polymer. Bangladesh J. Sci. Ind. Res.56(3), 165-176, 2021

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Section: Drug Release Kinetics Analysismentioning

confidence: 99%

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Sarkar¹,

Hossin²,

Hossain³

et al. 2021

Bangladesh J. Sci. Ind. Res.

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Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time

Kim,

Park,

Jeong

et al. 2024

Pharmaceutical Development and Technology

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Formulation and Evaluation of Oral Fast Dissolving Films of Naproxen Sodium

HYMA¹,

FATIMA²

2022

Int J Curr Pharm Sci

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Objective: The aim of this investigation was to prepare ODFs containing Naproxen Sodium, an NSAID, using solvent casting method and to evaluate them to put together a dosage form which can be taken without water, is easy to administer, has a rapid onset of action and can surmount first pass metabolism. Six distinct formulations of naproxen sodium ODF (F1-F6) were created in this investigation by varying the quantity of croscarmellose sodium, a super disintegrant. Methods: Naproxen Sodium ODF’s were prepared by solvent casting method. Evaluation of prepared ODF’s was done by considering various parameters such as film thickness, folding endurance, disintegration time, surface pH, weight variation, in vitro dissolution test, content uniformity and FTIR. Results: F6 has shown to be the best fast release formulation in terms of disintegration time (less than 1 minute) and dissolution (103.5 % after 30 min). Formulation F6's other film characteristics, such as weight variation, thickness, pH, and folding endurance, were all within the USP limit. Conclusion: By virtue of quick disintegration self-administration without water or chewing, oral fast dissolving film (OFDF) is one such new technique to enhance consumer acceptance. The film is an excellent intraoral fast-dissolving medication delivery method by which a wide range of medicines, including neuroleptics, cardiovascular drugs, analgesics, anti-asthmatic, antihistamines and drugs for erectile dysfunction, can be manufactured. From the standpoint of the patient, oromucosal medication delivery is appealing since it allows for easy administration without the need to swallow, as well as better patient safety. As a novel delivery mechanism, the notion of a quick-dissolving dosage form has gained popularity. By lowering dose frequency, this method will deliver optimum therapeutic efficacy, improved bioavailability, and maximum stability. This will also surmount first-pass metabolism of drugs. This method allows for faster medication absorption from the pre-gastric region, perhaps resulting in a faster onset of action.

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A comparative study on Naproxen Sodium tablets formulating with different super disintegrants

Cited by 3 publications

References 4 publications

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Enhancement of dissolution profile of poorly aqueous soluble atorvastatin calcium by binary and ternary solid dispersion techniques

Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time

Formulation and Evaluation of Oral Fast Dissolving Films of Naproxen Sodium

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