A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes

Agrawal

et al. 2012

Indian J Psychiatry

152

Background:Anxiety and depression form commonest stress-induced psychiatric disorders. To combat the biochemical changes which occur as a result of stress, there is antioxidant defence in the biological system. Secondary defence is by the nonenzymatic antioxidants like vitamins E (alphatocopherol), C (ascorbic acid), and β-carotene. Therefore, the authors interest was aroused to examine the status of these antioxidants in the biological system of patients suffering from stress-induced psychiatric disorders.Aims:This study was carried out to find out whether patients with generalized anxiety disorder (GAD) and depression have any difference in blood serum levels of vitamins A (β-carotene), C, and E in comparison to the normal healthy control group and whether supplementation of adequate doses of vitamins A (β-carotene), C, and E leads to improvement in anxiety and depression and reduction in scores of the patients.Materials and Methods:Eighty subjects in the age group of 20–60 years, who attended a psychiatric clinic of a private hospital and who met inclusion and exclusion criteria of the study and consented for psychological evaluation and blood screening to find out the serum levels of vitamins A, C, and E, were included in the study. Approval was sought from the institutional ethics committee for collecting the blood sample of these subjects before and after vitamins A, C, and E supplements given for a period of 6 weeks.Statistics Analysis:It was observed that patients with GAD and depression had significantly lower levels of vitamins A, C, and E in comparison to healthy controls. After dietary supplementation of these vitamins for a period of 6 weeks, a significant reduction in anxiety and depression scores of patients was observed (P<0.001). A significant increase in the blood levels of antioxidants was observed in patients (P<0.05) except that of vitamin E in the group of depressed patients.Results and Conclusion:The findings suggest that antioxidant supplement therapy as an adjuvant therapy is useful in patients with stress-induced psychiatric disorders and the results have been discussed.

Section: Introductionmentioning

confidence: 99%

Role of antioxidants in generalised anxiety disorder and depression

Agrawal

et al. 2012

Indian J Psychiatry

152

International Journal of Stroke

“…In animal rodent models, an increase in ceruloplasmin levels has been observed in response to transient ischemia, and lack of ceruloplasmin has led to increased damage from stroke (24, 25). Clinically, ceruloplasmin plays a role as an antioxidative effect in response to stroke (26) and because of this role could serve as a biomarker for ischemia. Ceruloplasmin was identified as a candidate biomarker in our initial proteomic screen but failed to reach significance in the second cohort of patients using ELISAs to measure serum concentrations.…”

Section: Discussionmentioning

confidence: 99%

Novel Tia Biomarkers Identified by Mass Spectrometry-Based Proteomics

George

Mlynash

Adams

et al. 2015

“…The pathophysiological processes involve the increased permeability of the bloodbrain barrier, energy failure, loss of cell ion homeostasis, acidosis, increased intracellular calcium, apoptosis, and neuronal death. 4 Human serum paraoxonase 1 (PON1) is an enzyme that has PON as well as arylesterase activity and is physically bound to high-density lipoproteins (HDL). It plays a key role in the biological action of HDL by protecting the lipoprotein, and by preventing the oxidative damage of the HDL biological membrane.…”

Section: Association Of Atherogenic Cardiac Index and Markers Of Oxid...mentioning

confidence: 99%

Association of atherogenic cardiac index and markers of oxidative stress in non-diabetic dyslipidemia stroke patients in a tertiary care hospital in Eastern India

Anannya Ghosh,

Apratim Chatterjee,

Sanchayan Sinha

2024

Asian J Med Sci

Background: Stroke is a clinical syndrome consisting of rapidly developing clinical signs of focal or global disturbance of cerebral function. Antioxidants are exogenous or endogenous compounds acting by scavenging reactive oxygen species or their precursors, inhibiting reactive oxygen species formation and binding metal ions needed for the catalysis of its generation. Atherogenic index, a predictor of atherosclerosis, increases in dyslipidemia also shows a positive association with oxidative stress. Aims and Objectives: Our objective was to compare the lipid profile, the markers of lipid peroxidation (malonaldehyde and paraoxonase [PON]), and atherogenic index in non-diabetic stroke patients with healthy controls and to evaluate the correlation between the lipid parameters with markers of lipid peroxidation and atherogenic index in those patients. Materials and Methods: One hundred diagnosed stroke patients from the Neurology department were compared with 100 age-matched healthy controls. Estimation of lipid profile parameters was done by AutoAnalyzer using standardized kits. Estimation of serum malonaldehyde was done based on the principle of utilization of Thiobarbituric acid. Serum PON1 activity was estimated using paranitrophenyl acetate substrate. Results: Among the lipid profile parameters, high-density lipoprotein (HDL) was significantly lower (P<0.001) and low-density lipoprotein (LDL) was significantly higher among stroke patients. Serum malonaldehyde level was significantly increased and PON1 activity was significantly decreased in stroke patients in comparison to healthy individuals. A significant positive correlation between HDL and PON1 and a negative correlation between LDL and PON1 were found. Atherogenic index is negatively correlated with PON1. Conclusion: Low level of PON1 activity and an increased level of malonaldehyde were found in stroke patients indicating an imbalance between free radical generation and its scavenging action and also associated with more chance of atherosclerosis.