A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial

Kim, Bong Hyun; Kim, Kyuseok; Nam, Hae Jeong

doi:10.1186/s12906-017-1589-3

Cited by 23 publications

(54 citation statements)

References 19 publications

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“…So far, only a few small trials for several conditions have directly compared the effects of manual and electrical acupuncture 3839404142. The findings of these studies were inconsistent and inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial

Luo

et al. 2020

BMJ

146

123

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Objective To assess the efficacy of manual acupuncture as prophylactic treatment for acupuncture naive patients with episodic migraine without aura. Design Multicentre, randomised, controlled clinical trial with blinded participants, outcome assessment, and statistician. Setting Seven hospitals in China, 5 June 2016 to 15 November 2018. Participants 150 acupuncture naive patients with episodic migraine without aura. Interventions 20 sessions of manual acupuncture at true acupuncture points plus usual care, 20 sessions of non-penetrating sham acupuncture at heterosegmental non-acupuncture points plus usual care, or usual care alone over 8 weeks. Main outcome measures Change in migraine days and migraine attacks per four weeks during weeks 1-20 after randomisation compared with baseline (four weeks before randomisation). Results Among 150 randomised patients (mean age 36.5 (SD 11.4) years; 123 (82%) women), 147 were included in the full analysis set. Compared with sham acupuncture, manual acupuncture resulted in a significantly greater reduction in migraine days at weeks 13 to 20 and a significantly greater reduction in migraine attacks at weeks 17 to 20. The reduction in mean number of migraine days was 3.5 (SD 2.5) for manual versus 2.4 (3.4) for sham (adjusted difference −1.4, 95% confidence interval −2.4 to −0.3; P=0.005) at weeks 13 to 16 and 3.9 (3.0) for manual versus 2.2 (3.2) for sham (adjusted difference −2.1, −2.9 to −1.2; P<0.001) at weeks 17 to 20. At weeks 17 to 20, the reduction in mean number of attacks was 2.3 (1.7) for manual versus 1.6 (2.5) for sham (adjusted difference −1.0, −1.5 to −0.5; P<0.001). No severe adverse events were reported. No significant difference was seen in the proportion of patients perceiving needle penetration between manual acupuncture and sham acupuncture (79% v 75%; P=0.891). Conclusions Twenty sessions of manual acupuncture was superior to sham acupuncture and usual care for the prophylaxis of episodic migraine without aura. These results support the use of manual acupuncture in patients who are reluctant to use prophylactic drugs or when prophylactic drugs are ineffective, and it should be considered in future guidelines. Trial registration Clinicaltrials.gov NCT02765581 .

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Section: Discussionmentioning

confidence: 99%

Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial

Luo

et al. 2020

BMJ

146

123

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“…Four basic acupoints near the ear (TE21, SI19, GB2, and TE17) were adopted in both groups. In the PADA group, 11 more acupoints were added according to the TCM theory and clinical research [13, 15, 26, 34, 35], including scalp acupoints (vestibulocochlear line), acupoints along the meridian, and distant acupoints. The acupoints along the meridian connecting with the ear were GB20 and GB34 (gallbladder meridian) and TE3 and TE5 (san jiao meridian).…”

Section: Discussionmentioning

confidence: 99%

“…A study in South Korea reported that systemic manual acupuncture showed better effects than periauricular electroacupuncture alone. The systemic manual acupuncture includes periauricular acupoints and distal acupoints in the limbs according to the meridian system theory [34]. Similarly, Rogha et al selected acupoints for tinnitus treatment according to the diagnostic pattern of TCM, plus four basic acupoints in the periauricular region (TE17, GB2, SI19, and TE21), in which patients with tinnitus had a better response to acupuncture treatment in that study [13].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Factors Influencing the Efficiency of Acupuncture in Tinnitus Patients

Lin

Yang

Lee

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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An effective acupuncture treatment must comprehend the influence of various factors, but studies in this aspect remain limited. This study aimed to identify relevant factors and search for the best practical method of acupuncture for patients with tinnitus. The study was a retrospective review of patients’ data with a prospective design who had subjective idiopathic tinnitus and received acupuncture between May 2012 and August 2017. Patients’ demographics, tinnitus characteristics, previous diseases, underlying diseases, oral habits, audiograms, acupuncture sessions, and acupoints were recorded and analyzed. A visual analog scale (VASloudness) was used for measuring the loudness of tinnitus, and the Clinical Global Impression-Improvement scale (CGI-I) was used for assessing the suffering of patients. Good treatment responses in patients were defined as the magnitude of change from the baseline VASloudness for ≥ 30% plus CGI-I ≤ 3 points. In total, 107 patients were enrolled. Most factors were not significantly associated with the treatment effectiveness of acupuncture in tinnitus patients. Only the combination of acupoints and the number of acupuncture sessions reached statistically significant differences. Further analyzing these two factors, we confirmed that the combination of periauricular and distal acupuncture and 17 to 24 acupuncture sessions contributed to a considerably better outcome. This result would serve as a reference for clinical acupuncturists to select an appropriate acupuncture strategy in the treatment of tinnitus.

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“…In previous studies applying TENS for tinnitus, electrodes were attached at the TMJ, earflaps, tragus, and C2 dermatome; the results indicate response rates from 17.9 to 82% [ 8 , 15 , 20 , 31 – 33 ]. The electrical stimulation of the C2 dermatome is known to control the excitement and inhibition of the dorsal cochlear nucleus through targeting cells in the dorsal column nucleus [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our previous study on tinnitus, the manual acupuncture group and distal electroacupuncture group showed a significant effect on VAS uncomfortable compared with the periauricular electroacupuncture group without systemic manual acupuncture [ 33 ], possibly due to the systemic acupuncture effect of the meridian system, such as the modulation of the autonomic nervous system and balancing of body and mind. In this study, to clarify the effect of TENS, MA, and EA on the autonomic nervous system, we will examine the skin conductance and HRV.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effectiveness between transcutaneous electrical nerve stimulation, manual acupuncture, and electroacupuncture on tinnitus: study protocol for a randomized controlled trial

Moon

Kim

Nam

2018

Trials

Self Cite

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BackgroundTranscutaneous electrical nerve stimulation (TENS) involves a neuromodulatory effect using electrical stimulation and has been widely used due to its safety and convenience. It has been used for treating tinnitus for decades. Acupuncture has also been used for tinnitus and several research studies have shown that acupuncture can improve a certain kind of tinnitus by stimulating the somatosensory system. Moreover, several studies have shown the efficacy of electroacupuncture, which is a combination of acupuncture and electrical stimulation, for tinnitus. However, the comparative effectiveness of TENS, manual acupuncture, and electroacupuncture for the treatment of tinnitus has not been determined previously. Herein, we design a randomized, non-blind clinical trial to investigate and compare the effects and safety of TENS, manual acupuncture, and electroacupuncture for tinnitus.MethodsAfter screening, 45 patients are randomly assigned to three groups: (1) patients in the TENS group are treated at four sites (tender points of masseter and the sternocleidomastoid muscle, in front of tragus, and mastoid process); (2) the manual acupuncture group patients are treated at 11 acupoints (TE21, SI19, GB2, TE22, ST7, TE17, GB20 of tinnitus affected side, and GB20, TE05, KI3 of both sides); (3) electroacupuncture group patients are treated by using acupuncture as in the manual acupuncture group and electrical stimulation at TE21, SI19, TE17, and GB20. Patients are treated for ten sessions, twice a week. The primary outcome measurement is the change of Tinnitus Handicap Inventory (THI) score between visit 1 and visit 10. The secondary outcome measurements are the response rate of THI, change in visual analogue scale associated with the loudness and annoyance of tinnitus, pure-tone audiometry and speech discrimination, and changes in parameters of heart rate variability.DiscussionThe purpose of this study is to compare the effect of TENS, manual acupuncture, and electroacupuncture in the auricular area on tinnitus. If the specific treatment shows a significant effect compared to other treatments, it could have potential for use in clinical practice as a primary treatment.Trial registrationClinical Research Information Service (CRIS), KCT0002117. Registered October 21, 2016. Retrospectively registered.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2738-9) contains supplementary material, which is available to authorized users.

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A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial

Cited by 23 publications

References 19 publications

Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial

Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial

Analysis of Factors Influencing the Efficiency of Acupuncture in Tinnitus Patients

Comparison of the effectiveness between transcutaneous electrical nerve stimulation, manual acupuncture, and electroacupuncture on tinnitus: study protocol for a randomized controlled trial

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