A Comparative Study on the Antibacterial Effects of Some Newly Synthesized Thiazole, Imidazolidine and Tetrahydropyrimidine Derivatives Against Bacillus cereus and Salmonella typhimurium

Ghasemi, Behzad; Beyzaei, Hamid; Majidiani, Hamidreza

doi:10.15171/ps.2016.10

Cited by 3 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sulfamethoxazole, the chemical structure "4-Amino-N-(5-methylisoxazol-3-yl) benzene sulfonamide" and the powder slightly soluble in water and dissolve in dilute solutions of sodium hydroxide [5]. Sulfamethoxazole belong to antibiotic group active against gram positive and negative bacteria such as Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus, aspergillus, leishmania parasite and Fusarium fungi [6,7] by inhibit the synthesis of nucleic acids of bacteria [ 8] through inhibit glutamic acids an essential component of folic acid synthesis Sulfa has broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral and antipyretic property.…”

Section: Introductionmentioning

confidence: 99%

Sol-gel Method Sulphamethaxazole Nanoparticle Synthesis and Antimicrobial Action

Issa¹,

Kadhum²,

Majed³

et al. 2021

IJOIR

View full text Add to dashboard Cite

Sulphamethaxazole is antibiotic used to treat several types of bacterial infections and gives double effect when used with trimethoprim by 1 to 5 of sulphamethaxazole. It has a broad spectrum effect on the positive and negative bacteria of Gram and fungi. The objective of this research is to convert sulfamethasazole to nano sulfamethasazole by Sol-gel method by using additive material like acetic acid, distilled water and ethanol with temperature 80°C and probe sonicator machine as catalyst and hydrolysis factor. Nano sulphamethoxazole solution analyzed by atomic force microscope (AFM) was show average of nano particles at size (50±10) nm. Scanned by TEM and SEM shows nano particles as a band of hollow tubes with a diameter less than 100 nm., beside the EDS pattern show high peaks of sodium, carbon and oxygen along with some other constituents. The antibacterial activity of nano solution shows respectable inhibition activity compared to slandered solution.

show abstract

Section: Introductionmentioning

confidence: 99%

Sol-gel Method Sulphamethaxazole Nanoparticle Synthesis and Antimicrobial Action

Issa¹,

Kadhum²,

Majed³

et al. 2021

IJOIR

View full text Add to dashboard Cite

show abstract

“…The 1,3-thiazole motif is one of the backbones of many bioactive natural products, such as vitamin B1 (thiamine), micrococcin, and thiostrepton . Thiazole-containing compounds are known for their broad medicinal and biological activities, including antitumor, anticancer, antiviral, anti-inflammatory, antitubercular, antibacterial, antifungal, antimalarial, antihypertensive, and anti-HIV (Figure A)…”

mentioning

confidence: 99%

“…The 1,3-thiazole motif is one of the backbones of many bioactive natural products, such as vitamin B1 (thiamine), 1 micrococcin, 2 and thiostrepton. 3 Thiazolecontaining compounds are known for their broad medicinal and biological activities, including antitumor, 4 anticancer, 5 antiviral, 6 anti-inflammatory, 7 antitubercular, 8 antibacterial, 9 antifungal, 10 antimalarial, 11 antihypertensive, 12 and anti-HIV (Figure 1A). 13 Furthermore, 2-aminothiazole as a derivative of this azoles, exhibits various medicinal and biological activities which have been utilized widely in the treatment of depression (Figure 1B), 14 inflammation (Figure 1C), 15 schizophrenia, 16 tuberculosis, 17 Parkinson's disease, 18 ulcers, 19 and HIV infections.…”

mentioning

confidence: 99%

Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds

et al. 2019

View full text Add to dashboard Cite

Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.

show abstract

Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe₃O₄@SiO₂ Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii. Methods: Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240 μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations. Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values. Results: Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations. Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024 µg ml-1) and MBCs (128-2048 µg ml-1). Conclusion: Among synthetic chemicals and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathologic effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.

show abstract

A Comparative Study on the Antibacterial Effects of Some Newly Synthesized Thiazole, Imidazolidine and Tetrahydropyrimidine Derivatives Against Bacillus cereus and Salmonella typhimurium

Cited by 3 publications

References 28 publications

Sol-gel Method Sulphamethaxazole Nanoparticle Synthesis and Antimicrobial Action

Sol-gel Method Sulphamethaxazole Nanoparticle Synthesis and Antimicrobial Action

Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds

Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe₃O₄@SiO₂ Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii

Contact Info

Product

Resources

About

A Comparative Study on the Antibacterial Effects of Some Newly Synthesized Thiazole, Imidazolidine and Tetrahydropyrimidine Derivatives Against Bacillus cereus and Salmonella typhimurium

Cited by 3 publications

References 28 publications

Sol-gel Method Sulphamethaxazole Nanoparticle Synthesis and Antimicrobial Action

Sol-gel Method Sulphamethaxazole Nanoparticle Synthesis and Antimicrobial Action

Aryliodoazide Synthons: A Different Approach for Diversified Synthesis of 2-Aminothiazole, 1,3-Thiazole, and 1,3-Selenazole Scaffolds

Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii

Contact Info

Product

Resources

About

Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe₃O₄@SiO₂ Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii