A Comparative Study on the Efficacy of Submucosal Injection of Dexamethasone Versus Methylprednisolone in Reducing Postoperative Sequelae After Third Molar Surgery

Lim, Daniel V.; Ngeow, Wei Cheong

doi:10.1016/j.joms.2017.05.033

Cited by 36 publications

(63 citation statements)

References 30 publications

(57 reference statements)

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“…A total of 800 titles were identified and 525 abstracts were reviewed. Full-text analysis included 18 articles and seven RCT were finally included [ 30-35 ]. One article was included as the result of hand-searching [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The included studies in the present systematic review consisted of seven hospital-based blinded RCT [ 30-36 ]. Different dosages of corticosteroids were assessed in four studies [ 30 , 32-34 ]. Different administration routes of corticosteroids were assessed in one study [ 36 ], and two studies assessed different dosages and administration routes of corticosteroids [ 31 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…A description of the used power calculation of sample size was not reported in any of the included studies. The method used for randomization was described in two studies, involving a random numbers table [ 30 ] or opaque envelopes [ 31 ]. Age distribution was described in five studies [ 31-34 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review

Larsen¹,

Kofod²,

Christiansen³

et al. 2018

JOMR

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ObjectivesThe objective of the present systematic review was to test the hypothesis of no difference in facial swelling, pain and trismus after surgical removal of mandibular third molar with different dosages of corticosteroids and administration routes.Material and MethodsA MEDLINE (PubMed), Embase database and Cochrane Library search in combination with a hand-search of relevant journals was conducted by including randomized controlled trials published in English until 1st December 2017.ResultsSeven studies fulfilled the inclusion criteria. Considerable variation in the included studies prevented meta-analysis from being performed. Preoperative submucosal injection of corticosteroids significantly diminishes facial swelling, pain and trismus compared with placebo. However, different dosages of corticosteroid and administration routes reveal contrary results indicating that administration of a higher dosage of corticosteroids do not necessarily cause a further decrease in facial swelling, pain and trismus.ConclusionsConsequently, the optimal dosage of corticosteroids and administration route for diminishing postsurgical morbidity and improve quality of life after surgical removal of mandibular third molar is presently unknown. Therefore, further well-designed randomized clinical trials including a standardised protocol, patient-reported outcome measures and three-dimensional analysis of facial swelling is needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review

Larsen¹,

Kofod²,

Christiansen³

et al. 2018

JOMR

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show abstract

“…In this study, the highest levels of trismus for both groups were recorded on the first post-surgical day, resolved almost entirely by the seventh day, a similar outcome to that reported by various studies. [27][28][29][30] Results showed that a higher degree of pain was recorded in the group that received pre-surgical dexamethasone compared to the post-surgical group, at 60 minutes after surgery. The reversed was observed after the 6-hour evaluation until the seventh post-surgical day.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the anti-inflammatory effectiveness of dexamethasone as pre-surgical and post-surgical therapy in mandibular third molar surgery: A randomized clinical trial.

et al. 2020

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Objective: To compare the anti-inflammatory effectiveness of dexamethasone as pre-surgical and post-surgical therapy in mandibular third molar surgery. Materials and methods: Randomized clinical trial conducted in 60 patients in need of mandibular third molar extraction, ages ranging from 16 to 35 years old, at the Department of Oral and Maxillofacial Surgery of the Arzobispo Loayza National Hospital during the period of January-March, 2016. Patients were distributed in two randomized groups: Group A received 4mg dexamethasone intramuscular before the surgery, and Group B received the same medication post-surgery. Facial edema was assessed using the distance between facial points, trismus was evaluated using the interincisal distance, and pain intensity was determined using a Numerical Scale (NS). Results: Facial edema values were lower in Group A at 60 minutes (p=0.002) and after the first (p=0.001) and third days (p=0.009), compared to Group B. Regarding trismus, no significant differences between the groups were found. Regarding pain intensity, the highest point was recorded at 6 hours in both groups; however, no significant differences between the groups were found. Conclusion: Pre-surgical dexamethasone administration produced a significantly greater reduction in facial edema after mandibular third molar surgery.

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Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial

et al. 2020

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A Comparative Study on the Efficacy of Submucosal Injection of Dexamethasone Versus Methylprednisolone in Reducing Postoperative Sequelae After Third Molar Surgery

Abstract: The study findings suggest that a single preoperative dose of dexamethasone versus methylprednisolone was equally effective in reducing postoperative swelling and trismus. Pain control by these corticosteroids, however, was variable.

Cited by 36 publications

References 30 publications

Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review

Different Dosages of Corticosteroid and Routes of Administration in Mandibular Third Molar Surgery: a Systematic Review

Comparison of the anti-inflammatory effectiveness of dexamethasone as pre-surgical and post-surgical therapy in mandibular third molar surgery: A randomized clinical trial.

Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial

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